Tanaka Tomohito, Nishie Ruri, Murakami Hikaru, Tsuchihashi Hiromitsu, Toji Akihiko, Ueda Shoko, Morita Natsuko, Hashida Sousuke, Terada Shinichi, Maruoka Hiroshi, Taniguchi Kohei, Komura Kazumasa, Ohmichi Masahide
Department of Obstetrics and Gynecology, Educational Foundation of Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki 569-8686, Osaka, Japan.
Center for Medical Research & Development, Division of Translational Research, Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki 569-8686, Osaka, Japan.
J Clin Med. 2024 Jul 8;13(13):3981. doi: 10.3390/jcm13133981.
: The sentinel lymph node is the first node that cancer cells reach when migrating from the primary site. However, oncological outcomes after sentinel lymph node biopsy (SNB) have not been reported for cervical cancer. In this study, oncological outcomes were compared between patients receiving SNB and pelvic lymphadenectomy (PLD) for early-stage cervical cancer. : One hundred and four patients with clinical stage 1A2, 1B1, and 2A1 cervical cancer were included in this study. All patients underwent laparoscopic or robot-assisted radical hysterectomy with SNB or PLD. Fifty-two patients with tumors ≤2 cm underwent SNB. Disease-free survival (DFS) and overall survival (OS) were compared between the groups. : The median (interquartile range) tumor size was 12 (7-20) mm in the SNB group and 20 (13-25) mm in the PLD group. Lymph node metastasis occurred in one patient in the SNB group and in nine patients in the PLD group. The median follow-up periods were 42 (24-60) and 82 (19-101) months in the SNB group and PLD group, respectively. The 3-year DFS rates were 100% in SNB and 91.5% in PLD. The 3-year OS was 100% in both groups. : SNB was sufficient in cervical cancer patients with tumors ≤2 cm, suggesting that PLD might not be necessary for these patients.
前哨淋巴结是癌细胞从原发部位转移时最先到达的淋巴结。然而，尚未有关于宫颈癌前哨淋巴结活检（SNB）后肿瘤学结局的报道。在本研究中，对早期宫颈癌接受SNB和盆腔淋巴结清扫术（PLD）的患者的肿瘤学结局进行了比较。
本研究纳入了104例临床分期为1A2、1B1和2A1期的宫颈癌患者。所有患者均接受了腹腔镜或机器人辅助根治性子宫切除术及SNB或PLD。52例肿瘤≤2 cm的患者接受了SNB。比较了两组的无病生存期（DFS）和总生存期（OS）。
SNB组的中位（四分位间距）肿瘤大小为12（7 - 20）mm，PLD组为20（13 - 25）mm。SNB组有1例患者发生淋巴结转移，PLD组有9例。SNB组和PLD组的中位随访时间分别为42（24 - 60）个月和82（19 - 101）个月。SNB组的3年DFS率为100%，PLD组为91.5%。两组的3年OS均为100%。
对于肿瘤≤2 cm的宫颈癌患者，SNB已足够，这表明这些患者可能无需进行PLD。
