Clinical Trial Institution Office, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China.
Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China.
Nutrients. 2024 Jul 6;16(13):2154. doi: 10.3390/nu16132154.
Research on maternal weight gain in early pregnancy with healthy live offspring is lacking for Chinese women. Based on the China birth cohort study (CBCS), we aimed to explore maternal weight gain in different groups.
Singleton pregnancies of 6 ~13 weeks of gestation from the CBCS were considered, not including missing data or outliers, those lost at follow-up, or those with non-typical conditions of the offspring. Maternal first-trimester weight and body mass index (BMI) gain was considered as the early pregnancy weight minus the pre-pregnancy weight. Using Pearson's or Spearman's correlation and linear regression models to explore the relationship between maternal weight and BMI gain and gestational age (GA), stratified and sensitivity analyses were carried out to identify the study's robustness.
There were 25,292 singleton pregnancies with healthy live offspring who were ultimately enrolled, and there was a linear correlation between GA and maternal weight gain (=0.55 + 0.05 × GA (weeks), < 0.001, r = 0.002) and BMI change (=0.21 + 0.02 × GA (weeks), < 0.001, r = 0.002). The association remained robust in the stratified and sensitivity analyses of the subgroups.
Although the association between GA and maternal pre-pregnancy weight and BMI gain is weak, a slight correlation was shown, especially in pregnant women with a typical or low pre-pregnancy BMI, Han ethnicity, moderate levels of physical activity, natural conception, and folic acid (FA) and/or multivitamin supplementation.
针对中国女性，缺乏关于孕早期健康活产儿的母体体重增加的研究。基于中国出生队列研究（CBCS），我们旨在探讨不同组别中母亲的体重增加情况。
考虑来自 CBCS 的孕 6~13 周的单胎妊娠，不包括缺失数据或异常值、随访丢失的妊娠，以及不符合子女非典型情况的妊娠。母体孕早期体重和体重指数（BMI）增加被认为是孕早期体重减去孕前体重。使用 Pearson 或 Spearman 相关和线性回归模型来探讨母体体重和 BMI 增加与孕龄（GA）之间的关系，进行分层和敏感性分析以确定研究的稳健性。
共有 25292 例具有健康活产子女的单胎妊娠最终纳入研究，GA 与母体体重增加（=0.55+0.05×GA（周），<0.001，r=0.002）和 BMI 变化（=0.21+0.02×GA（周），<0.001，r=0.002）之间存在线性相关。在亚组的分层和敏感性分析中，该关联仍然稳健。
尽管 GA 与母体孕前体重和 BMI 增加之间的关联较弱，但显示出轻微的相关性，尤其是在具有典型或低孕前 BMI、汉族、中高水平体力活动、自然受孕、以及叶酸（FA）和/或多种维生素补充的孕妇中。
