Poulsen S S, Nexø E, Olsen P S, Kirkegaard P
Histochem J. 1985 Apr;17(4):487-92. doi: 10.1007/BF01003208.
A serine protease, ingobsin, that cleaves Lys-x and Arg-x, has been purified from rat duodenal tissue. By immunohistochemical methods, the enzyme was localized in goblet cells in the small intestine of rat, pig, and man. The immunoreactive cells were most numerous in the proximal part of the intestine. In the electron microscope, the immunoreaction was localized mainly to the rough endoplasmic reticulum of the goblet cells and to the secretion being extruded from the cells.
一种能切割赖氨酸-X和精氨酸-X的丝氨酸蛋白酶——肠杯状细胞蛋白酶，已从大鼠十二指肠组织中纯化出来。通过免疫组织化学方法，该酶定位于大鼠、猪和人的小肠杯状细胞中。免疫反应性细胞在小肠近端最为丰富。在电子显微镜下，免疫反应主要定位于杯状细胞的粗面内质网以及从细胞中挤出的分泌物上。
