杯状细胞丝氨酸蛋白酶（肠杯蛋白）的分泌受血管活性肠肽和乙酰胆碱的刺激。

Secretion of goblet cell serine proteinase, ingobsin, is stimulated by vasoactive intestinal polypeptide and acetylcholine.

作者信息

Kvist N, Olsen P S, Poulsen S S, Nexø E

机构信息

Department of Clinical Chemistry, Central Hospital, Hillerød, Denmark.

出版信息

Digestion. 1987;37(4):223-7. doi: 10.1159/000199505.

DOI:10.1159/000199505

PMID:3479368

Abstract

Ingobsin is localized to the intestinal goblet cells in the rat and in man. In the present study, we investigated the effect of vasoactive intestinal polypeptide (VIP) and acetylcholine on the secretion of ingobsin from the proximal duodenum. Intravenous infusion of VIP or acetylcholine increased the concentration of ingobsin in duodenal secretion, while the concentration in the duodenum was unchanged. Simultaneous infusion of VIP and acetylcholine increased the concentration of ingobsin in duodenal secretion and decreased the concentration of ingobsin in the duodenum. This study demonstrates that secretion of ingobsin from the proximal duodenum is exocrine and can be stimulated by VIP and acetylcholine.

摘要

英戈辛定位于大鼠和人类的肠道杯状细胞中。在本研究中，我们研究了血管活性肠肽（VIP）和乙酰胆碱对十二指肠近端英戈辛分泌的影响。静脉输注VIP或乙酰胆碱可增加十二指肠分泌物中英戈辛的浓度，而十二指肠中的浓度未发生变化。同时输注VIP和乙酰胆碱可增加十二指肠分泌物中英戈辛的浓度，并降低十二指肠中英戈辛的浓度。本研究表明，十二指肠近端英戈辛的分泌是外分泌性的，且可被VIP和乙酰胆碱刺激。