深入了解口腔鳞状细胞癌分子机制的新见解。
New Insights for an Advanced Understanding of the Molecular Mechanisms in Oral Squamous Cell Carcinoma.
机构信息
Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Titu Maiorescu University, 031593 Bucharest, Romania.
Department of Oral and Maxillofacial Surgery, Carol Davila Central Military Emergency Hospital, 010825 Bucharest, Romania.
出版信息
Int J Mol Sci. 2024 Jun 26;25(13):6964. doi: 10.3390/ijms25136964.
Abstract
Oral squamous cell carcinoma (OSCC), the most common type of head and neck cancer, remains a highly challenging cancer to treat, largely due to the late diagnosis in advanced stages of the disease, which occurs in more than half of cases [...].
摘要
口腔鳞状细胞癌（OSCC）是最常见的头颈部癌症，仍然是一种极具挑战性的癌症，主要是因为疾病晚期的诊断较晚，超过一半的病例[……]。
相似文献
1
New Insights for an Advanced Understanding of the Molecular Mechanisms in Oral Squamous Cell Carcinoma.深入了解口腔鳞状细胞癌分子机制的新见解。
Int J Mol Sci. 2024 Jun 26;25(13):6964. doi: 10.3390/ijms25136964.
2
Malignant Transformation of Normal Oral Tissue to Dysplasia and Early Oral Squamous Cell Carcinoma: An Transcriptomics Approach.正常口腔组织向发育异常和早期口腔鳞状细胞癌的恶性转化：一种转录组学方法。
Anal Cell Pathol (Amst). 2024 Sep 18;2024:6260651. doi: 10.1155/2024/6260651. eCollection 2024.
3
HNRNPA2B1 promotes oral squamous cell carcinogenesis via mA-dependent stabilization of FOXQ1 mRNA stability.HNRNPA2B1通过依赖于N6-甲基腺苷（mA）的FOXQ1 mRNA稳定性的稳定作用促进口腔鳞状细胞癌发生。
IUBMB Life. 2024 Jul;76(7):437-450. doi: 10.1002/iub.2808. Epub 2024 Jan 24.
4
Knockdown of RABL3 suppresses the proliferation and invasion of oral squamous cell carcinoma through inactivating the FAK/AKT pathway.敲低 RABL3 通过抑制 FAK/AKT 通路抑制口腔鳞状细胞癌的增殖和侵袭。
J Bioenerg Biomembr. 2021 Apr;53(2):203-211. doi: 10.1007/s10863-021-09871-x. Epub 2021 Jan 12.
5
WNT3 promotes chemoresistance to 5-Fluorouracil in oral squamous cell carcinoma via activating the canonical β-catenin pathway.WNT3 通过激活经典的β-catenin 通路促进口腔鳞状细胞癌对 5-氟尿嘧啶的耐药性。
BMC Cancer. 2024 May 6;24(1):564. doi: 10.1186/s12885-024-12318-2.
6
Aberrated PSMA1 expression associated with clinicopathological features and prognosis in oral squamous cell carcinoma.PSMA1 表达异常与口腔鳞状细胞癌的临床病理特征和预后相关。
Odontology. 2024 Jul;112(3):950-958. doi: 10.1007/s10266-023-00883-0. Epub 2024 Jan 12.
7
Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma.肿瘤抑制因子 SMAD4 与 WNT 信号通路在口腔鳞状细胞癌进展中的相互作用。
J Pathol. 2024 Sep;264(1):4-16. doi: 10.1002/path.6318. Epub 2024 Jun 26.
8
CDK1 and CCNA2 play important roles in oral squamous cell carcinoma.CDK1 和 CCNA2 在口腔鳞状细胞癌中发挥重要作用。
Medicine (Baltimore). 2024 Apr 19;103(16):e37831. doi: 10.1097/MD.0000000000037831.
9
Heat Shock Proteins 70 Regulate Cell Motility and Invadopodia-Associated Proteins Expression in Oral Squamous Cell Carcinoma.热休克蛋白70调节口腔鳞状细胞癌中的细胞运动性和侵袭伪足相关蛋白表达。
Front Endocrinol (Lausanne). 2022 Jul 26;13:890218. doi: 10.3389/fendo.2022.890218. eCollection 2022.
10
LncRNA FOXD2-AS1 promotes the growth, invasion and migration of OSCC cells by regulating the MiR-185-5p/PLOD1/Akt/mTOR pathway.长链非编码 RNA FOXD2-AS1 通过调控 miR-185-5p/PLOD1/Akt/mTOR 通路促进口腔鳞状细胞癌细胞的生长、侵袭和迁移。
Cancer Genet. 2024 Jun;284-285:48-57. doi: 10.1016/j.cancergen.2024.05.001. Epub 2024 May 6.
引用本文的文献
1
Integrating Genetic Insights and Artificial Intelligence for Enhanced Oral and Maxillofacial Cancer Care.整合基因见解与人工智能以加强口腔颌面癌护理。
Methods Mol Biol. 2025;2952:107-124. doi: 10.1007/978-1-0716-4690-8_7.
2
Expression of CSTF2 in oral squamous cell carcinoma and its relationship with immune infiltration and poor prognosis.CSTF2在口腔鳞状细胞癌中的表达及其与免疫浸润和预后不良的关系。
Front Oral Health. 2025 Feb 7;6:1548829. doi: 10.3389/froh.2025.1548829. eCollection 2025.
本文引用的文献
1
Potential applications of JAK inhibitors, clinically approved drugs against autoimmune diseases, in cancer therapy.JAK抑制剂（临床上已获批用于治疗自身免疫性疾病的药物）在癌症治疗中的潜在应用。
Front Pharmacol. 2024 Jan 3;14:1326281. doi: 10.3389/fphar.2023.1326281. eCollection 2023.
2
Oral squamous cell carcinomas: state of the field and emerging directions.口腔鳞状细胞癌：研究现状与新兴方向。
Int J Oral Sci. 2023 Sep 22;15(1):44. doi: 10.1038/s41368-023-00249-w.
3
Salivary Chemical Barrier Proteins in Oral Squamous Cell Carcinoma-Alterations in the Defense Mechanism of the Oral Cavity.口腔鳞状细胞癌中的唾液化学屏障蛋白——口腔防御机制的改变。
Int J Mol Sci. 2023 Sep 4;24(17):13657. doi: 10.3390/ijms241713657.
4
Early Diagnosis of Oral Cancer: A Complex Polyhedral Problem with a Difficult Solution.口腔癌的早期诊断：一个复杂的多面体问题，解决方案困难。
Cancers (Basel). 2023 Jun 21;15(13):3270. doi: 10.3390/cancers15133270.
5
Combination Therapy as a Promising Way to Fight Oral Cancer.联合治疗作为对抗口腔癌的一种有前景的方法。
Pharmaceutics. 2023 Jun 4;15(6):1653. doi: 10.3390/pharmaceutics15061653.
6
Identification of Somatic Mutations in Plasma Cell-Free DNA from Patients with Metastatic Oral Squamous Cell Carcinoma.鉴定转移性口腔鳞状细胞癌患者血浆游离 DNA 中的体细胞突变。
Int J Mol Sci. 2023 Jun 20;24(12):10408. doi: 10.3390/ijms241210408.
7
Semilicoisoflavone B Induces Apoptosis of Oral Cancer Cells by Inducing ROS Production and Downregulating MAPK and Ras/Raf/MEK Signaling.二氢马兜铃内酰胺 B 通过诱导 ROS 产生和下调 MAPK 和 Ras/Raf/MEK 信号通路诱导口腔癌细胞凋亡。
Int J Mol Sci. 2023 Feb 24;24(5):4505. doi: 10.3390/ijms24054505.
8
Chemotherapeutic Drug Resistance Associated with Differential miRNA Expression of miR-375 and miR-27 among Oral Cancer Cell Lines.化疗药物耐药性与口腔癌细胞系中 miR-375 和 miR-27 的差异 miRNA 表达相关。
Int J Mol Sci. 2023 Jan 8;24(2):1244. doi: 10.3390/ijms24021244.
9
Targeted therapy for head and neck cancer: signaling pathways and clinical studies.头颈部癌症的靶向治疗：信号通路与临床研究。
Signal Transduct Target Ther. 2023 Jan 16;8(1):31. doi: 10.1038/s41392-022-01297-0.
10
Role Played by Paraoxonase-2 Enzyme in Cell Viability, Proliferation and Sensitivity to Chemotherapy of Oral Squamous Cell Carcinoma Cell Lines.对氧磷酶 2 酶在口腔鳞状细胞癌细胞活力、增殖和化疗敏感性中的作用。
Int J Mol Sci. 2022 Dec 25;24(1):338. doi: 10.3390/ijms24010338.
Zotero 插件