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候选基因和有利单倍型与水稻铁毒性耐受相关。

Candidate Genes and Favorable Haplotypes Associated with Iron Toxicity Tolerance in Rice.

机构信息

State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100081, China.

College of Agronomy, Anhui Agricultural University, Hefei 230036, China.

出版信息

Int J Mol Sci. 2024 Jun 26;25(13):6970. doi: 10.3390/ijms25136970.

DOI:10.3390/ijms25136970
PMID:39000075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11241266/
Abstract

Iron (Fe) toxicity is a major issue adversely affecting rice production worldwide. Unfortunately, the physiological and genetic mechanisms underlying Fe toxicity tolerance in rice remain relatively unknown. In this study, we conducted a genome-wide association study using a diverse panel consisting of 551 rice accessions to identify genetic mechanisms and candidate genes associated with Fe toxicity tolerance. Of the 29 quantitative trait loci (QTL) for Fe toxicity tolerance detected on chromosomes 1, 2, 5, and 12, five (, , , , and ) were selected to identify candidate genes according to haplotype and bioinformatics analyses. The following five genes were revealed as promising candidates: , , , , and . The physiological characteristics of rice accessions with contrasting Fe toxicity tolerance reflected the importance of reactive oxygen species-scavenging antioxidant enzymes and Fe homeostasis for mitigating the negative effects of Fe toxicity on rice. Our findings have clarified the genetic and physiological mechanisms underlying Fe toxicity tolerance in rice. Furthermore, we identified valuable genetic resources for future functional analyses and the development of Fe toxicity-tolerant rice varieties via marker-assisted selection.

摘要

铁（Fe）毒性是一个全球性的问题，严重影响着水稻的生产。不幸的是，水稻对 Fe 毒性耐受的生理和遗传机制仍知之甚少。在这项研究中，我们利用由 551 个水稻品种组成的多样性群体进行了全基因组关联研究，以鉴定与 Fe 毒性耐受相关的遗传机制和候选基因。在检测到的位于 1、2、5 和 12 号染色体上的 29 个 Fe 毒性耐受数量性状位点（QTL）中，根据单倍型和生物信息学分析，选择了五个（、、、、和）来鉴定候选基因。以下五个基因被揭示为有希望的候选基因：、、、、和。具有不同 Fe 毒性耐受能力的水稻品种的生理特征反映了活性氧清除抗氧化酶和 Fe 稳态对于减轻 Fe 毒性对水稻的负面影响的重要性。我们的研究结果阐明了水稻 Fe 毒性耐受的遗传和生理机制。此外，我们通过标记辅助选择，鉴定了有价值的遗传资源，用于未来的功能分析和 Fe 毒性耐受水稻品种的开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11241266/7866a8474c72/ijms-25-06970-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11241266/3ad80138c5e5/ijms-25-06970-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11241266/3a3b7f3e3eda/ijms-25-06970-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11241266/6871d7547443/ijms-25-06970-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11241266/13ff850d47e2/ijms-25-06970-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11241266/7866a8474c72/ijms-25-06970-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11241266/3ad80138c5e5/ijms-25-06970-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11241266/3a3b7f3e3eda/ijms-25-06970-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11241266/6871d7547443/ijms-25-06970-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11241266/13ff850d47e2/ijms-25-06970-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11241266/7866a8474c72/ijms-25-06970-g005.jpg

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