Engineering Research Center of Protection and Utilization of Plant Resources, College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang 110866, China.
Int J Mol Sci. 2024 Jun 27;25(13):7081. doi: 10.3390/ijms25137081.
Furofuran lignans have been identified as the main substances responsible for the biological activities of the plant genus . Here, four new phrymarolin-type leptolignans A-D (-) and eight previously known lignans were isolated from . Of these, nine exhibited significant antifeedant activity against armyworm () through a dual-choice bioassay, with the EC values ranging from 0.58 to 10.08 μg/cm. In particular, the newly identified lignan leptolignan A () showed strong antifeedant activity, with an EC value of 0.58 ± 0.34 μg/cm. Further investigation found that leptolignan A can inhibit the growth and nutritional indicators in the armyworm . The concentrations of two molting hormones, 20-hydroxyecdysone and ecdysone, were also found to decrease significantly following the treatment of the armyworms with the lignan, implying that the target of the lignan may be involved in 20-hydroxyecdysone and ecdysone synthesis. These results enrich our knowledge of metabolite structural diversity, and provide a theoretical basis for the control of armyworm using lignans.
呋喃木脂素已被确定为该植物属生物活性的主要物质。在这里，从 中分离得到了四个新的 phrymarolin 型 leptolignans A-D（-）和八个先前已知的木脂素。其中，通过双选择生物测定法，有 9 种对行军虫（）表现出显著的拒食活性，EC 值范围为 0.58 至 10.08μg/cm。特别是新鉴定的木脂素 leptolignan A（）表现出强烈的拒食活性，EC 值为 0.58±0.34μg/cm。进一步的研究发现，leptolignan A 可以抑制行军虫的生长和营养指标。还发现两种蜕皮激素 20-羟基蜕皮酮和蜕皮酮的浓度在木质素处理行军虫后显著降低，这意味着木质素的靶标可能涉及 20-羟基蜕皮酮和蜕皮酮的合成。这些结果丰富了我们对 代谢物结构多样性的认识，并为利用木质素控制行军虫提供了理论依据。
