Pham Tuan D, Tsunoyama Taichiro
Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AD, UK.
School of Medicine, Teikyo University, Tokyo 173-0003, Japan.
Cancers (Basel). 2024 Jun 24;16(13):2308. doi: 10.3390/cancers16132308.
Extravasation, the unintended leakage of intravenously administered substances, poses significant challenges in cancer treatment, particularly during chemotherapy and radiotherapy. This comprehensive review explores the pathophysiology, incidence, risk factors, clinical presentation, diagnosis, prevention strategies, management approaches, complications, and long-term effects of extravasation in cancer patients. It also outlines future directions and research opportunities, including identifying gaps in the current knowledge and proposing areas for further investigation in extravasation prevention and management. Emerging technologies and therapies with the potential to improve extravasation prevention and management in both chemotherapy and radiotherapy are highlighted. Such innovations include advanced vein visualization technologies, smart catheters, targeted drug delivery systems, novel topical treatments, and artificial intelligence-based image analysis. By addressing these aspects, this review not only provides healthcare professionals with insights to enhance patient safety and optimize clinical practice but also underscores the importance of ongoing research and innovation in improving outcomes for cancer patients experiencing extravasation events.
外渗是指静脉注射药物意外渗漏,在癌症治疗中,尤其是化疗和放疗期间,会带来重大挑战。这篇综述全面探讨了癌症患者外渗的病理生理学、发生率、危险因素、临床表现、诊断、预防策略、处理方法、并发症及长期影响。还概述了未来的方向和研究机会,包括找出当前知识的空白,并提出在预防和处理外渗方面进一步研究的领域。重点介绍了有潜力改善化疗和放疗中外渗预防和处理的新兴技术和疗法。这些创新包括先进的静脉可视化技术、智能导管、靶向给药系统、新型局部治疗以及基于人工智能的图像分析。通过阐述这些方面,本综述不仅为医护人员提供了增强患者安全和优化临床实践的见解,还强调了持续研究和创新对于改善发生外渗事件的癌症患者治疗效果的重要性。