Kimbrough ErinMarie O, Marin-Acevedo Julian A, Drusbosky Leylah M, Mooradian Ariana, Zhao Yujie, Manochakian Rami, Lou Yanyan
Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.
Department of Hematology and Oncology, Division of Internal Medicine, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA.
Cancers (Basel). 2024 Jun 27;16(13):2366. doi: 10.3390/cancers16132366.
Genomic mutations impact non-small cell lung cancer (NSCLC) biology. The influence of sex and age on the distribution of these alterations is unclear. We analyzed circulating-tumor DNA from individuals with advanced NSCLC from March 2018 to October 2020. , , , , , , , , , , , and alterations were assessed. We evaluated the differences by sex and age (<70 and ≥70) using Fisher's exact test. Of the 34,277 samples, 30,790 (89.83%) had a detectable mutation and 19,923 (58.12%) had an alteration of interest. The median age of the ctDNA positive population was 69 (18-102), 16,756 (54.42%) were female, and 28,835 (93.65%) had adenocarcinoma. Females had more alterations in all the assessed mutations, G12C, and ex20 ins. Males had higher numbers of amp and alterations in and . Patients <70 years were more likely to have alterations in exon 19 del/exon 20 ins/T790M, G12C/D, , , V600E, Ex20ins, amp, and . Individuals ≥70 years were more likely to have alterations in L861Q, exon 14 skipping, and . We provided evidence of sex- and age-associated differences in the distribution of genomic alterations in individuals with advanced NSCLC.
基因组突变影响非小细胞肺癌（NSCLC）生物学。性别和年龄对这些改变分布的影响尚不清楚。我们分析了2018年3月至2020年10月晚期NSCLC患者的循环肿瘤DNA。评估了……、……、……、……、……、……、……、……、……、……、……和……改变。我们使用Fisher精确检验按性别和年龄（<70岁和≥70岁）评估差异。在34277个样本中，30790个（89.83%）有可检测到的突变，19923个（58.12%）有感兴趣的改变。ctDNA阳性人群的中位年龄为69岁（18 - 102岁），16756名（54.42%）为女性，28835名（93.65%）患有腺癌。女性在所有评估的……突变、G12C和……外显子20插入中有更多改变。男性有更多的……扩增以及……和……中的改变。<70岁的患者更有可能在外显子19缺失/外显子20插入/T790M、……G12C/D、……、……、……V600E、……外显子20插入、……扩增、……和……中有改变。≥70岁的个体更有可能在L861Q、外显子14跳跃和……中有改变。我们提供了晚期NSCLC患者基因组改变分布中与性别和年龄相关差异的证据。
