Sex- and Age-Associated Differences in Genomic Alterations among Patients with Advanced Non-Small Cell Lung Cancer (NSCLC).

Genomic mutations impact non-small cell lung cancer (NSCLC) biology. The influence of sex and age on the distribution of these alterations is unclear. We analyzed circulating-tumor DNA from individuals with advanced NSCLC from March 2018 to October 2020. , , , , , , , , , , , and alterations were assessed. We evaluated the differences by sex and age (<70 and ≥70) using Fisher's exact test. Of the 34,277 samples, 30,790 (89.83%) had a detectable mutation and 19,923 (58.12%) had an alteration of interest. The median age of the ctDNA positive population was 69 (18-102), 16,756 (54.42%) were female, and 28,835 (93.65%) had adenocarcinoma. Females had more alterations in all the assessed mutations, G12C, and ex20 ins. Males had higher numbers of amp and alterations in and . Patients <70 years were more likely to have alterations in exon 19 del/exon 20 ins/T790M, G12C/D, , , V600E, Ex20ins, amp, and . Individuals ≥70 years were more likely to have alterations in L861Q, exon 14 skipping, and . We provided evidence of sex- and age-associated differences in the distribution of genomic alterations in individuals with advanced NSCLC.