Martín-Sanz Raquel, Rodrigues-Françoso Aline, García-Mesa Yolanda, García-Alonso Francisco Javier, Gómez-Muñoz María Asunción, Malmierca-González Sandra, Salazar-Blázquez Rocío, García-Suárez Olivia, Feito Jorge
Instituto de Investigación Biomédica de Salamanca (IBSAL), 37007 Salamanca, Spain.
Servicio de Oftalmología, Complejo Asistencial de Zamora, 49022 Zamora, Spain.
Cancers (Basel). 2024 Jun 29;16(13):2413. doi: 10.3390/cancers16132413.
In the last decade, a group of Ca channels called Piezo were discovered, demonstrating a decisive role in the cellular response to mechanical stimuli and being essential in the biological behavior of cells regarding the extracellular compartment. Several investigations have suggested a potential role in carcinogenesis, with a tumor suppressor role in some cases but increased expression in several high-grade neoplasms. Regarding Piezo2 expression in mammary gland neoplasms, a protective role for Piezo2 was initially suggested, but a subsequent study demonstrated a relationship between Piezo2 expression and the highly aggressive triple-negative phenotype of breast carcinoma. A cohort of 125 patients with clinical follow-up was chosen to study Piezo2 expression and clarify its clinical implications using the same immunohistochemical evaluation performed for other breast carcinoma parameters. Fisher's exact test was chosen to identify potential relationships between the different variables. A significant association was found with the Ki67 proliferation index, but not with mitoses. The tendency of most proliferative tumors was to have an increased score for Piezo2. A similar association was found between Piezo2 expression and perineural invasion.
在过去十年中，发现了一组名为Piezo的钙通道，它们在细胞对机械刺激的反应中起决定性作用，并且在细胞关于细胞外区室的生物学行为中至关重要。多项研究表明其在致癌过程中具有潜在作用，在某些情况下起肿瘤抑制作用，但在几种高级别肿瘤中表达增加。关于Piezo2在乳腺肿瘤中的表达，最初认为Piezo2具有保护作用，但随后的一项研究表明Piezo2表达与乳腺癌的高侵袭性三阴性表型之间存在关联。选择了一组125例有临床随访的患者，使用与其他乳腺癌参数相同的免疫组织化学评估方法来研究Piezo2表达并阐明其临床意义。选择Fisher精确检验来确定不同变量之间的潜在关系。发现与Ki67增殖指数存在显著关联，但与有丝分裂无关。大多数增殖性肿瘤倾向于Piezo2评分增加。在Piezo2表达与神经周围侵犯之间也发现了类似的关联。
