Karska Julia, Kowalski Szymon, Saczko Jolanta, Moisescu Mihaela G, Kulbacka Julita
Faculty of Medicine, Wroclaw Medical University, 50-345 Wroclaw, Poland.
Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Membranes (Basel). 2023 Jan 29;13(2):167. doi: 10.3390/membranes13020167.
Mechanical forces are an inherent element in the world around us. The effects of their action can be observed both on the macro and molecular levels. They can also play a prominent role in the tissues and cells of animals due to the presence of mechanosensitive ion channels (MIChs) such as the Piezo and TRP families. They are essential in many physiological processes in the human body. However, their role in pathology has also been observed. Recent discoveries have highlighted the relationship between these channels and the development of malignant tumors. Multiple studies have shown that MIChs mediate the proliferation, migration, and invasion of various cancer cells via various mechanisms. This could show MIChs as new potential biomarkers in cancer detection and prognosis and interesting therapeutic targets in modern oncology. Our paper is a review of the latest literature on the role of the Piezo1 and TRP families in the molecular mechanisms of carcinogenesis in different types of cancer.
机械力是我们周围世界的一个固有元素。其作用效果在宏观和分子层面都能被观察到。由于存在诸如Piezo和TRP家族等机械敏感离子通道（MIChs），它们在动物的组织和细胞中也能发挥显著作用。它们在人体许多生理过程中至关重要。然而，它们在病理学中的作用也已被观察到。最近的发现突出了这些通道与恶性肿瘤发展之间的关系。多项研究表明，MIChs通过各种机制介导各种癌细胞的增殖、迁移和侵袭。这可能表明MIChs是癌症检测和预后的新潜在生物标志物，也是现代肿瘤学中有趣的治疗靶点。我们的论文是对Piezo1和TRP家族在不同类型癌症致癌分子机制中作用的最新文献综述。
