Atkinson R L, Kaiser D L
J Am Coll Nutr. 1985;4(4):411-9. doi: 10.1080/07315724.1985.10720084.
The relative contributions of weight loss vs calorie restriction in the improvement of glucose tolerance in obese subjects has not been well studied. We measured fasting and stimulated glucose and insulin levels in seven obese subjects at 4 time periods: on a regular diet before weight loss, on a very low calorie ketogenic diet (VLCKD) after 4 days and after 6 weeks, and after 4 days back on a regular diet. Fasting glucose and insulin levels fell significantly after only 4 days of calorie restriction and did not change after 6 weeks. With return to a regular diet, these levels rose toward baseline even through body weight remained well below baseline. Stimulated glucose and insulin levels during an insulin tolerance test, intravenous glucose tolerance test, and standard meal demonstrated a similar pattern, although the changes due to either diet or weight loss were minimal. We conclude that calorie restriction has a greater effect on glucose and insulin levels than does weight loss in obese subjects who are losing weight.
在肥胖受试者中，体重减轻与热量限制对改善糖耐量的相对贡献尚未得到充分研究。我们在4个时间段测量了7名肥胖受试者的空腹及刺激后的血糖和胰岛素水平：体重减轻前的常规饮食阶段、4天后及6周后的极低热量生酮饮食（VLCKD）阶段，以及恢复常规饮食4天后。仅在热量限制4天后，空腹血糖和胰岛素水平就显著下降，6周后未发生变化。恢复常规饮食后，尽管体重仍远低于基线水平，但这些水平向基线上升。胰岛素耐量试验、静脉葡萄糖耐量试验和标准餐期间的刺激后血糖和胰岛素水平呈现类似模式，尽管饮食或体重减轻引起的变化很小。我们得出结论，在体重减轻的肥胖受试者中，热量限制对血糖和胰岛素水平的影响大于体重减轻。
