Liu Shuoyuan, Zhao Huayuan, Jiang Tao, Wan Gui, Yan Chengqi, Zhang Chi, Yang Xiaofan, Chen Zhenbing
Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of Urology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China.
Stem Cell Rev Rep. 2024 Oct;20(7):1795-1812. doi: 10.1007/s12015-024-10762-y. Epub 2024 Jul 13.
Stem cells-derived extracellular vesicles (SC-EVs) have emerged as promising therapeutic agents for wound repair, recapitulating the biological effects of parent cells while mitigating immunogenic and tumorigenic risks. These EVs orchestrate wound healing processes, notably through modulating angiogenesis-a critical event in tissue revascularization and regeneration. This study provides a comprehensive overview of the multifaceted mechanisms underpinning the pro-angiogenic capacity of EVs from various stem cell sources within the wound microenvironment. By elucidating the molecular intricacies governing their angiogenic prowess, we aim to unravel the mechanistic repertoire underlying their remarkable potential to accelerate wound healing. Additionally, methods to enhance the angiogenic effects of SC-EVs, current limitations, and future perspectives are highlighted, emphasizing the significant potential of this rapidly advancing field in revolutionizing wound healing strategies.
干细胞衍生的细胞外囊泡（SC-EVs）已成为伤口修复中有前景的治疗剂，它重现了亲代细胞的生物学效应，同时降低了免疫原性和致瘤风险。这些细胞外囊泡协调伤口愈合过程，特别是通过调节血管生成——这是组织再血管化和再生中的关键事件。本研究全面概述了伤口微环境中来自各种干细胞来源的细胞外囊泡促血管生成能力背后的多方面机制。通过阐明控制其血管生成能力的分子复杂性，我们旨在揭示其加速伤口愈合巨大潜力背后的机制。此外，还强调了增强SC-EVs血管生成作用的方法、当前的局限性以及未来的前景，突出了这一快速发展领域在彻底改变伤口愈合策略方面的巨大潜力。
