Dettlaff Anna, Rycewicz Michał, Macewicz Łukasz, Rutecki Paweł, Sawczak Mirosław, Wittendorp Paul, Jain Shruti, Vereshchagina Elizaveta, Bogdanowicz Robert
Gdańsk University of Technology, 11/12 Gabriela Narutowicza Street, 80-233, Gdańsk, Poland.
Gdańsk University of Technology, 11/12 Gabriela Narutowicza Street, 80-233, Gdańsk, Poland.
Talanta. 2024 Oct 1;278:126519. doi: 10.1016/j.talanta.2024.126519. Epub 2024 Jul 8.
There is growing interest in developing diamond electrodes with defined geometries such as, for example, micrometer-sized electrode arrays to acquire signals for electroanalysis. For electroanalytical sensing applications, it is essential to achieve precise conductive patterns on the insulating surface. This work provides a novel approach to boron-doped diamond patterning using nichrome masking for selective seeding on an oxidized silicon substrate. The optimized process involves nichrome deposition, sonication, chemical etching, seeding, and tailored chemical vapor deposition of boron-doped diamond with an intrinsic layer to suppress boron diffusion. Through a systematic investigation, it was determined that isolated boron-doped diamond band electrodes can be efficiently produced on non-conductive silica. Additionally, the influence of boron doping on electrochemical performance was studied, with higher doping enhancing the electrochemical response of band electrodes. To demonstrate sensing capabilities, boron-doped diamond bands were used to detect posaconazole, an antifungal drug, exploiting its electroactive behaviour. A linear correlation between posaconazole concentration and oxidation peak current was observed over 1.43 × 10 - 5.71 × 10 M with a 1.4 × 10 M detection limit. The developed boron-doped diamond microbands could significantly impact the field of electroanalysis, facilitating detection of diverse biologically relevant molecules. Overall, this diamond patterning approach overcomes major challenges towards all-diamond electrochemical sensor chips.
人们对开发具有特定几何形状的金刚石电极越来越感兴趣，例如微米级电极阵列，用于获取电分析信号。对于电分析传感应用，在绝缘表面实现精确的导电图案至关重要。这项工作提供了一种新颖的方法，使用镍铬合金掩膜在氧化硅衬底上进行选择性晶种生长，以实现硼掺杂金刚石的图案化。优化后的工艺包括镍铬合金沉积、超声处理、化学蚀刻、晶种生长以及对具有本征层的硼掺杂金刚石进行定制化学气相沉积，以抑制硼扩散。通过系统研究，确定了可以在非导电二氧化硅上高效制备孤立的硼掺杂金刚石带电极。此外，研究了硼掺杂对电化学性能的影响，较高的掺杂增强了带电极的电化学响应。为了展示传感能力，利用硼掺杂金刚石带检测抗真菌药物泊沙康唑的电活性行为。在1.43×10 - 5.71×10 M范围内观察到泊沙康唑浓度与氧化峰电流之间的线性关系，检测限为1.4×10 M。所开发的硼掺杂金刚石微带可能会对电分析领域产生重大影响，有助于检测各种与生物相关的分子。总体而言，这种金刚石图案化方法克服了全金刚石电化学传感器芯片面临的主要挑战。
