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Fosfomycin-resistance plasmids determine an intracellular modification of fosfomycin.

作者信息

León J, García-Lobo J M, Navas J, Ortiz J M

出版信息

J Gen Microbiol. 1985 Jul;131(7):1649-55. doi: 10.1099/00221287-131-7-1649.

DOI:10.1099/00221287-131-7-1649
PMID:3900283
Abstract

Escherichia coli cells carrying fosfomycin-resistance plasmids modify fosfomycin intracellularly. The product of this modification (fosfomycin-derivative) differs from fosfomycin in chromatographic mobility, but the chemical nature of the modification is not yet known. Fosfomycin-derivative appears to have a cytoplasmic location and lacks antibiotic activity. The modification system can be saturated by an excess of fosfomycin in the incubation media.

摘要

相似文献

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引用本文的文献

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Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal Gene.革兰氏阴性菌中由染色体基因导致的广泛磷霉素耐药性
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2
Molecular Mechanisms and Clinical Impact of Acquired and Intrinsic Fosfomycin Resistance.获得性和固有磷霉素耐药的分子机制及临床影响。
Antibiotics (Basel). 2013 Apr 16;2(2):217-36. doi: 10.3390/antibiotics2020217.
3
Formation of an adduct between fosfomycin and glutathione: a new mechanism of antibiotic resistance in bacteria.
磷霉素与谷胱甘肽之间加合物的形成：细菌抗生素耐药性的一种新机制。
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4
Fosfomycin trometamol: activity in vitro against urinary tract pathogens.
Infection. 1990;18 Suppl 2:S60-4. doi: 10.1007/BF01643429.
5
Nucleotide sequence and intracellular location of the product of the fosfomycin resistance gene from transposon Tn2921.转座子Tn2921中磷霉素抗性基因产物的核苷酸序列及细胞内定位
Antimicrob Agents Chemother. 1990 Oct;34(10):2016-8. doi: 10.1128/AAC.34.10.2016.
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Plasmid-encoded fosfomycin resistance.质粒编码的磷霉素耐药性
Antimicrob Agents Chemother. 1991 May;35(5):791-5. doi: 10.1128/AAC.35.5.791.