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Antimicrob Agents Chemother. 1985 Jul;28(1):163-4. doi: 10.1128/AAC.28.1.163.
2
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10
Cloning and molecular epidemiology of plasmid-determined fosfomycin resistance.
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本文引用的文献

1
Fosfomycin resistance plasmids do not affect fosfomycin transport into Escherichia coli.磷霉素抗性质粒不影响磷霉素转运进入大肠杆菌。
Antimicrob Agents Chemother. 1982 Apr;21(4):608-12. doi: 10.1128/AAC.21.4.608.
2
Plasmid-determined resistance to fosfomycin in Serratia marcescens.粘质沙雷氏菌中质粒介导的对磷霉素的耐药性。
Antimicrob Agents Chemother. 1980 Aug;18(2):215-9. doi: 10.1128/AAC.18.2.215.
3
[Prevalence and dispersion of plasmids conferring fosfomycin resistance in enterobacteria].[肠杆菌科细菌中携带磷霉素耐药质粒的流行情况及分布]
Pathol Biol (Paris). 1984 Sep;32(7):755-8.
4
Fosfomycin inactivates its target enzyme in Escherichia coli cells carrying a fosfomycin resistance plasmid.磷霉素可使携带磷霉素抗性质粒的大肠杆菌细胞中的靶酶失活。
Antimicrob Agents Chemother. 1983 Aug;24(2):276-8. doi: 10.1128/AAC.24.2.276.
5
Cloning and expression in minicells of the determinant of resistance to fosfomycin from the transposon Tn2921.
Plasmid. 1984 May;11(3):243-7. doi: 10.1016/0147-619x(84)90030-1.
6
The mechanism of action of fosfomycin (phosphonomycin).磷霉素的作用机制。
Ann N Y Acad Sci. 1974 May 10;235(0):364-86. doi: 10.1111/j.1749-6632.1974.tb43277.x.
7
Charactertization of spontaneous fosfomycin (phosphonomycin)-resistant cells of Escherichia coli B in vitro.体外大肠杆菌B自发磷霉素抗性细胞的特性研究。
J Antibiot (Tokyo). 1975 Nov;28(11):906-11. doi: 10.7164/antibiotics.28.906.

质粒介导的磷霉素耐药性是由于抗生素的酶促修饰所致。

Plasmid-mediated fosfomycin resistance is due to enzymatic modification of the antibiotic.

作者信息

Llaneza J, Villar C J, Salas J A, Suarez J E, Mendoza M C, Hardisson C

出版信息

Antimicrob Agents Chemother. 1985 Jul;28(1):163-4. doi: 10.1128/AAC.28.1.163.

DOI:10.1128/AAC.28.1.163
PMID:3899003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176334/
Abstract

The molecular mechanism of plasmid-mediated resistance to fosfomycin is described. The antibiotic was inactivated intracellularly and remained inside the cells. Modification was also obtained from cell extracts and was not energy dependent. The modifying enzyme seems to have sulfhydryl groups in its active center.

摘要

描述了质粒介导的对磷霉素耐药的分子机制。抗生素在细胞内被灭活并保留在细胞内。从细胞提取物中也获得了修饰作用，且不依赖能量。修饰酶的活性中心似乎含有巯基。