质粒介导的磷霉素耐药性是由于抗生素的酶促修饰所致。
Plasmid-mediated fosfomycin resistance is due to enzymatic modification of the antibiotic.
作者信息
Llaneza J, Villar C J, Salas J A, Suarez J E, Mendoza M C, Hardisson C
出版信息
Antimicrob Agents Chemother. 1985 Jul;28(1):163-4. doi: 10.1128/AAC.28.1.163.
Abstract
The molecular mechanism of plasmid-mediated resistance to fosfomycin is described. The antibiotic was inactivated intracellularly and remained inside the cells. Modification was also obtained from cell extracts and was not energy dependent. The modifying enzyme seems to have sulfhydryl groups in its active center.
摘要
描述了质粒介导的对磷霉素耐药的分子机制。抗生素在细胞内被灭活并保留在细胞内。从细胞提取物中也获得了修饰作用，且不依赖能量。修饰酶的活性中心似乎含有巯基。
相似文献
1
Plasmid-mediated fosfomycin resistance is due to enzymatic modification of the antibiotic.质粒介导的磷霉素耐药性是由于抗生素的酶促修饰所致。
Antimicrob Agents Chemother. 1985 Jul;28(1):163-4. doi: 10.1128/AAC.28.1.163.
2
Fosfomycin resistance plasmids do not affect fosfomycin transport into Escherichia coli.磷霉素抗性质粒不影响磷霉素转运进入大肠杆菌。
Antimicrob Agents Chemother. 1982 Apr;21(4):608-12. doi: 10.1128/AAC.21.4.608.
3
[Plasmid resistance to fosfomycin].
G Ital Chemioter. 1979 Jan-Dec;26(1-2):189-94.
4
Molecular relationship among fosfomycin-resistant plasmids and clinical impact of fosfomycin resistance.
Microbiologica. 1988 Oct;11(4):289-97.
5
Identification of FosA8, a Plasmid-Encoded Fosfomycin Resistance Determinant from Escherichia coli, and Its Origin in Leclercia adecarboxylata.鉴定大肠埃希菌中一种由质粒编码的磷霉素耐药决定因子 FosA8 及其在莱氏柠檬酸杆菌中的起源。
Antimicrob Agents Chemother. 2019 Oct 22;63(11). doi: 10.1128/AAC.01403-19. Print 2019 Nov.
6
Fosfomycin inactivates its target enzyme in Escherichia coli cells carrying a fosfomycin resistance plasmid.磷霉素可使携带磷霉素抗性质粒的大肠杆菌细胞中的靶酶失活。
Antimicrob Agents Chemother. 1983 Aug;24(2):276-8. doi: 10.1128/AAC.24.2.276.
7
The detection of fosfomycin resistance genes in Enterobacteriaceae from pets and their owners.宠物及其主人肠道杆菌科细菌中磷霉素耐药基因的检测
Vet Microbiol. 2016 Sep 25;193:67-71. doi: 10.1016/j.vetmic.2016.07.019. Epub 2016 Jul 25.
8
Plasmid-determined resistance to fosfomycin in Serratia marcescens.粘质沙雷氏菌中质粒介导的对磷霉素的耐药性。
Antimicrob Agents Chemother. 1980 Aug;18(2):215-9. doi: 10.1128/AAC.18.2.215.
9
[Prevalence and dispersion of plasmids conferring fosfomycin resistance in enterobacteria].[肠杆菌科细菌中携带磷霉素耐药质粒的流行情况及分布]
Pathol Biol (Paris). 1984 Sep;32(7):755-8.
10
Emergence of Plasmid-Mediated Fosfomycin-Resistance Genes among Escherichia coli Isolates, France.法国大肠杆菌分离株中质粒介导的磷霉素抗性基因的出现
Emerg Infect Dis. 2017 Sep;23(9):1564-1567. doi: 10.3201/eid2309.170560.
引用本文的文献
1
Differences in Fosfomycin Resistance Mechanisms between Pseudomonas aeruginosa and .铜绿假单胞菌与. 之间磷霉素耐药机制的差异。
Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0144621. doi: 10.1128/AAC.01446-21. Epub 2021 Nov 22.
2
The Complex Relationship between Virulence and Antibiotic Resistance.毒力与抗生素耐药性之间的复杂关系。
Genes (Basel). 2017 Jan 18;8(1):39. doi: 10.3390/genes8010039.
3
Molecular Mechanisms and Clinical Impact of Acquired and Intrinsic Fosfomycin Resistance.获得性和固有磷霉素耐药的分子机制及临床影响。
Antibiotics (Basel). 2013 Apr 16;2(2):217-36. doi: 10.3390/antibiotics2020217.
4
Fosfomycin: Uses and potentialities in veterinary medicine.磷霉素：在兽医学中的用途及潜力
Open Vet J. 2014;4(1):26-43. Epub 2014 Mar 16.
5
Coagulase-negative staphylococci.凝固酶阴性葡萄球菌
Clin Microbiol Rev. 2014 Oct;27(4):870-926. doi: 10.1128/CMR.00109-13.
6
Structure and function of the genomically encoded fosfomycin resistance enzyme, FosB, from Staphylococcus aureus.金黄色葡萄球菌基因组编码的磷霉素抗性酶FosB的结构与功能
Biochemistry. 2014 Feb 4;53(4):755-65. doi: 10.1021/bi4015852. Epub 2014 Jan 21.
7
Fosfomycin: an old, new friend?磷霉素：故友还是新朋？
Eur J Clin Microbiol Infect Dis. 2010 Feb;29(2):127-42. doi: 10.1007/s10096-009-0833-2. Epub 2009 Nov 14.
8
Glutathione-dependent conversion of N-ethylmaleimide to the maleamic acid by Escherichia coli: an intracellular detoxification process.大肠杆菌通过谷胱甘肽依赖性将N-乙基马来酰亚胺转化为马来酰胺酸：一种细胞内解毒过程。
Appl Environ Microbiol. 2000 Apr;66(4):1393-9. doi: 10.1128/AEM.66.4.1393-1399.2000.
9
Product of fosC, a gene from Pseudomonas syringae, mediates fosfomycin resistance by using ATP as cosubstrate.丁香假单胞菌基因fosC的产物通过利用ATP作为共底物介导磷霉素抗性。
Antimicrob Agents Chemother. 1995 Jul;39(7):1569-73. doi: 10.1128/AAC.39.7.1569.
10
Cloning and molecular epidemiology of plasmid-determined fosfomycin resistance.
Antimicrob Agents Chemother. 1986 Feb;29(2):309-14. doi: 10.1128/AAC.29.2.309.
本文引用的文献
1
Fosfomycin resistance plasmids do not affect fosfomycin transport into Escherichia coli.磷霉素抗性质粒不影响磷霉素转运进入大肠杆菌。
Antimicrob Agents Chemother. 1982 Apr;21(4):608-12. doi: 10.1128/AAC.21.4.608.
2
Plasmid-determined resistance to fosfomycin in Serratia marcescens.粘质沙雷氏菌中质粒介导的对磷霉素的耐药性。
Antimicrob Agents Chemother. 1980 Aug;18(2):215-9. doi: 10.1128/AAC.18.2.215.
3
[Prevalence and dispersion of plasmids conferring fosfomycin resistance in enterobacteria].[肠杆菌科细菌中携带磷霉素耐药质粒的流行情况及分布]
Pathol Biol (Paris). 1984 Sep;32(7):755-8.
4
Fosfomycin inactivates its target enzyme in Escherichia coli cells carrying a fosfomycin resistance plasmid.磷霉素可使携带磷霉素抗性质粒的大肠杆菌细胞中的靶酶失活。
Antimicrob Agents Chemother. 1983 Aug;24(2):276-8. doi: 10.1128/AAC.24.2.276.
5
Cloning and expression in minicells of the determinant of resistance to fosfomycin from the transposon Tn2921.
Plasmid. 1984 May;11(3):243-7. doi: 10.1016/0147-619x(84)90030-1.
6
The mechanism of action of fosfomycin (phosphonomycin).磷霉素的作用机制。
Ann N Y Acad Sci. 1974 May 10;235(0):364-86. doi: 10.1111/j.1749-6632.1974.tb43277.x.
7
Charactertization of spontaneous fosfomycin (phosphonomycin)-resistant cells of Escherichia coli B in vitro.体外大肠杆菌B自发磷霉素抗性细胞的特性研究。
J Antibiot (Tokyo). 1975 Nov;28(11):906-11. doi: 10.7164/antibiotics.28.906.
Zotero 插件