Qu Yuyao, Ma Jixian, Di Rong, Bian Yue, Li Yuchen, Zhang Hanze, Qin Yazhou, Liu Qiuping, Lei Jianqin, Li Jingming
Department of Ophthalmology, First Affiliated Hospital of Xi'an Jiaotong University, Yanta Road, Xi'an, Shaanxi, 710061, China.
Department of Ophthalmology, First Affiliated Hospital of South China University, Hengyang, China.
BMC Ophthalmol. 2024 Dec 18;24(1):529. doi: 10.1186/s12886-024-03784-0.
This study was to evaluate the features of choroidal Sattler's and Haller's layer (CSHL) vessels in adults and explore its relationship with factors such as age, axial length (AL) and body mass index (BMI) by using ultra-widefield swept-source optical coherence tomography angiography (ultra-widefield SS-OCTA).
24mm × 20mm fovea centered rectangular SS-OCTA scans were acquired. They were divided into 9 identical grids, with each equal size of 8 mm × 6.7 mm. OCTA artifacts were evaluated. Three-dimensional choroidal vascularity volume index (CVI) and choroidal vascular volume per unit area (CVV/a or CVV) of CSHL were calculated. The correlations of CVI and CVV with age, AL, and BMI were analyzed.
Artifacts account for 19.30%, 18.60%, 30.23% of three inferior grids, respectively. CVI and CVV of left eyes were 30.82 ± 0.28% and 76.76 ± 2.19μm, respectively. Similary, CVI and CVV of right eyes were 31.16 ± 0.34% and 80.49 ± 3.10μm. Strong relationships of CVI (0.877, P = 0.000) and CVV (0.866, P = 0.000) were found between the two eyes in the same individual. The covariance of CVI is lower than that of CVV. Higher CVI was associated with younger age and shorter AL. Neither CVI nor CVV has association with BMI.
CVI can be a more stable parameter for describing choroidal medium and large-sized vessels compared to CVV. Aging and longer AL were associated with attenuated CSHL's vascularity. Taken together, these findings may provide helpful and referential CSHL vascular parameters for retinal specialists to reveal risk factors of choroidal diseases.
本研究旨在利用超广角扫频源光学相干断层扫描血管造影（超广角SS-OCTA）评估成年人脉络膜萨特勒层和哈勒层（CSHL）血管的特征，并探讨其与年龄、眼轴长度（AL）和体重指数（BMI）等因素的关系。
获取以黄斑中心凹为中心的24mm×20mm矩形SS-OCTA扫描图像。将其分为9个相同的网格，每个网格大小为8mm×6.7mm。评估OCTA伪影。计算CSHL的三维脉络膜血管容积指数（CVI）和单位面积脉络膜血管容积（CVV/a或CVV）。分析CVI和CVV与年龄、AL和BMI的相关性。
伪影分别占三个下方网格的19.30%、18.60%、30.23%。左眼的CVI和CVV分别为30.82±0.28%和76.76±2.19μm。同样，右眼的CVI和CVV分别为31.16±0.34%和80.49±3.10μm。在同一个体的双眼之间发现CVI（0.877，P = 0.000）和CVV（0.866，P = 0.000）有很强的相关性。CVI的协方差低于CVV。较高的CVI与较年轻的年龄和较短的AL相关。CVI和CVV均与BMI无关。
与CVV相比，CVI可能是描述脉络膜中大型血管的更稳定参数。衰老和较长的AL与CSHL血管减少有关。综上所述，这些发现可能为视网膜专家揭示脉络膜疾病的危险因素提供有用的参考性CSHL血管参数。
