Barber R W
J Nucl Med. 1985 Oct;26(10):1190-4.
A model is presented which enables radiation doses following the administration of technetium-99m diethylenetriaminepentaacetic acid ([99mTc]DTPA) aerosol to be calculated. The organ with potentially the highest radiation dose is shown to be the bladder wall. Radiation doses to the lungs, kidneys, and bladder wall and the effective whole-body dose are discussed in terms of the lung clearance rate of [99mTc]DTPA aerosol and the pattern of bladder voiding. The model indicated the influence of urine flow rate on bladder dose assuming a critical volume at which bladder voiding occurs. It is concluded that significant reductions in radiation doses may be achieved by encouraging patients or subjects undergoing investigations using [99mTc]DTPA aerosols to drink freely following the study.
本文提出了一种模型，该模型能够计算出在给予锝-99m二乙三胺五乙酸（[99mTc]DTPA）气雾剂后所产生的辐射剂量。结果表明，辐射剂量潜在最高的器官是膀胱壁。根据[99mTc]DTPA气雾剂的肺部清除率和膀胱排尿模式，讨论了肺部、肾脏、膀胱壁的辐射剂量以及全身有效剂量。该模型假设膀胱排尿发生时的临界体积，指出了尿流率对膀胱剂量的影响。得出的结论是，对于接受[99mTc]DTPA气雾剂检查的患者或受试者，鼓励他们在检查后自由饮水，可能会显著降低辐射剂量。
