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高浓度大麻花和大麻浓缩物对日常生活记忆和决策的急性影响。

Acute effects of high-potency cannabis flower and cannabis concentrates on everyday life memory and decision making.

机构信息

Department of Psychology, Washington State University, PO Box 644820, Pullman, WA, 99164-4820, USA.

出版信息

Sci Rep. 2021 Jul 2;11(1):13784. doi: 10.1038/s41598-021-93198-5.

DOI:10.1038/s41598-021-93198-5
PMID:34215784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8253757/
Abstract

Statewide legislation has increased public access to high-potency cannabis flower and concentrates, yet federal restrictions limit researchers' access to relatively low-potency whole-plant cannabis. The goal of this study was to examine the acute effects of high-potency cannabis on cognition using a novel methodology. We further sought to compare cognitive effects of high-potency cannabis flower with and without cannabidiol (CBD), as well as cannabis concentrates to cannabis flower. 80 cannabis users were randomly assigned to stay sober or use their funds to purchase one of three high-potency cannabis products: (1) high-potency flower (≥ 20% THC) without CBD, (2) high-potency flower with CBD, (3) high-potency concentrates (≥ 60% THC) with CBD. Participants were observed over Zoom videoconferencing while inhaling their product or remaining sober and then were administered tests of everyday life memory (prospective, source, temporal order, and false memory) and decision making (risky choice framing, consistency in risk perception, resistance to sunk cost, and over/under confidence) over Zoom. High-potency cannabis flower with CBD impaired free recall, high-potency flower without CBD and concentrates had detrimental effects on source memory, and all three products increased susceptibility to false memories. CBD did not offset impairments and concentrates were self-titrated producing comparable intoxication and impairment as flower.

摘要

全州范围内的立法增加了公众对高浓度大麻花和浓缩物的获取，但联邦限制限制了研究人员对相对低浓度全植物大麻的获取。本研究的目的是使用新方法检查高浓度大麻对认知的急性影响。我们还试图比较高浓度大麻花与不含大麻二酚 (CBD) 的高浓度大麻花以及大麻浓缩物对高浓度大麻花的认知影响。80 名大麻使用者被随机分配保持清醒或使用他们的资金购买三种高浓度大麻产品之一：(1) 不含 CBD 的高浓度花（≥20% THC），(2) 含 CBD 的高浓度花，(3) 含 CBD 的高浓度浓缩物（≥60% THC）。参与者在 Zoom 视频会议中被观察到吸入他们的产品或保持清醒，然后在 Zoom 上进行日常生活记忆（前瞻性、来源、时间顺序和虚假记忆）和决策（风险选择框架、风险感知一致性、抵制沉没成本和过度/不足自信）测试。含 CBD 的高浓度大麻花损害了自由回忆，不含 CBD 的高浓度花和浓缩物对来源记忆有不利影响，所有三种产品都增加了对虚假记忆的易感性。CBD 并没有抵消损害，而且浓缩物是自我滴定的，产生了与花相当的致醉和损害。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae74/8253757/f1be7876cb27/41598_2021_93198_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae74/8253757/bf918a699f67/41598_2021_93198_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae74/8253757/2473a85419d4/41598_2021_93198_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae74/8253757/98b0525320a5/41598_2021_93198_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae74/8253757/f1be7876cb27/41598_2021_93198_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae74/8253757/bf918a699f67/41598_2021_93198_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae74/8253757/2473a85419d4/41598_2021_93198_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae74/8253757/98b0525320a5/41598_2021_93198_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae74/8253757/f1be7876cb27/41598_2021_93198_Fig4_HTML.jpg

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