丁丙诺啡与吗啡对比：单中心回顾性研究中对新生儿阿片类药物戒断综合征（NOWS）结局的影响
Buprenorphine vs. morphine: impact on neonatal opioid withdrawal syndrome (NOWS) outcomes in a single center retrospective study.
作者信息
Anbalagan Saminathan, Anderson Victoria, Favara Michael T, Stark Daniela, Carola David, Solarin Kolawole, Adeniyi-Jones Susan, Kraft Walter K, Aghai Zubair H
机构信息
Deparment of Pediatrics/Neonatology, Thomas Jefferson University/Nemours, Philadelphia, PA, USA.
Deparment of Pediatrics/Neonatology, University of South Alabama, Mobile, AL, USA.
出版信息
J Perinatol. 2025 Apr;45(4):473-479. doi: 10.1038/s41372-024-02046-7. Epub 2024 Jul 13.
OBJECTIVES
To compare clinical outcomes for infants with neonatal opioid withdrawal syndrome (NOWS) treated with buprenorphine or morphine.
STUDY DESIGN
Retrospective study of infants born ≥35 weeks' gestation and admitted to the NICU for NOWS treatment between 2011 and 2022. Length of treatment, length of stay in the hospital, and the need for secondary medications were compared between buprenorphine and morphine treated neonates. Multiple regression analysis was performed, adjusting for baseline differences and confounders.
RESULTS
417 neonates were treated with morphine and 232 with buprenorphine. The buprenorphine group had shorter treatment days [-10.8 days; 95% CI: -8.08 to -13.53] and shorter hospital stay [-11.8 days; 95% CI: -8.83 to -14.78]. The buprenorphine group was no more likely to receive phenobarbital or clonidine (26% vs. 29%).
CONCLUSION
In this large single-center study, buprenorphine was associated with shorter lengths of treatment and hospital stay in the treatment of NOWS compared to morphine.
目的
比较接受丁丙诺啡或吗啡治疗的新生儿阿片类药物戒断综合征（NOWS）婴儿的临床结局。
研究设计
对2011年至2022年间出生孕周≥35周并因NOWS治疗入住新生儿重症监护病房（NICU）的婴儿进行回顾性研究。比较丁丙诺啡和吗啡治疗的新生儿的治疗时长、住院时长以及使用二线药物的必要性。进行多元回归分析，对基线差异和混杂因素进行校正。
结果
417例新生儿接受吗啡治疗，232例接受丁丙诺啡治疗。丁丙诺啡组的治疗天数较短[-10.8天；95%置信区间：-8.08至-13.53]，住院时间较短[-11.8天；95%置信区间：-8.83至-14.78]。丁丙诺啡组接受苯巴比妥或可乐定治疗的可能性并不更高（26%对29%）。
结论
在这项大型单中心研究中，与吗啡相比，丁丙诺啡在治疗NOWS时治疗时长和住院时间较短。
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