疾病中的过氧化物酶体。

Peroxisomes in disease.

作者信息

Goldfischer S

出版信息

J Histochem Cytochem. 1979 Oct;27(10):1371-3. doi: 10.1177/27.10.390036.

DOI:10.1177/27.10.390036

Abstract

Cytochemical, biochemical and morphological changes in peroxisomes have been described in human metabolic disorders, in experimental models of disease and in response to drugs and toxins. These include the cerebrohepatorenal syndromes, in which peroxisomes can not be detected and mitochondrial respiration is inhibited, atherosclerosis, alcoholic cardiomyopathy, and tolerance to oxygen toxicity. Although information on the role of peroxisomes in disease is limited, increased awareness of their widespread distribution and the availability of an improved cytochemical procedure for staining peroxisomes in human specimens should provide new insights into their function.

摘要

在人类代谢紊乱、疾病实验模型以及对药物和毒素的反应中，过氧化物酶体的细胞化学、生物化学和形态学变化已有相关描述。这些情况包括脑肝肾综合征（其中无法检测到过氧化物酶体且线粒体呼吸受到抑制）、动脉粥样硬化、酒精性心肌病以及对氧毒性的耐受性。尽管关于过氧化物酶体在疾病中的作用的信息有限，但对其广泛分布的认识不断提高，以及在人类标本中对过氧化物酶体进行染色的改进细胞化学方法的出现，应该会为其功能提供新的见解。