Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India..
Acta Histochem. 2024 Oct;126(5-7):152173. doi: 10.1016/j.acthis.2024.152173. Epub 2024 Jul 14.
Reproductive impairment is the most prevalent yet most ignored complication of diabetes mellitus. In diabetes, the problem associated with reproductive health is comprehensive in both males and females. Diabetic females have problems like delayed menarche, irregular menstrual cycle, subfertility, complications in pregnancy and early menopause. This may decrease reproductive age in diabetic females as the menarche is delayed and menopause is early in them. Like diabetic males, diabetic females also have the negative effect of oxidative stress on the reproductive system. This may lead to dysfunction of the ovary. It affects the physiological cycle like the ovary's maturation, embryo development and pregnancy. These complications also affect the offspring, and they may also become diabetic. This review aims to concentrate on the effect of diabetes on the reproductive system of females and the impairment caused by it. We will also discuss in detail the role of the hypothalamus-pituitary ovary axis, diabetes impact on different reproductive phases of females, and the sexual disorders that occur in them.
生殖障碍是糖尿病最常见但也最容易被忽视的并发症之一。在糖尿病中，与生殖健康相关的问题在男性和女性中都很普遍。糖尿病女性存在诸如初潮延迟、月经周期不规律、不孕、妊娠并发症和早绝经等问题。这可能会降低糖尿病女性的生育年龄，因为她们的初潮延迟，绝经较早。与糖尿病男性一样，糖尿病女性的生殖系统也受到氧化应激的负面影响。这可能导致卵巢功能障碍。它会影响卵巢的成熟、胚胎发育和妊娠等生理周期。这些并发症还会影响后代，他们也可能患上糖尿病。本综述旨在集中讨论糖尿病对女性生殖系统的影响及其造成的损害。我们还将详细讨论下丘脑-垂体-卵巢轴的作用、糖尿病对女性不同生殖阶段的影响以及她们中出现的性功能障碍。
