Lee Jong Hoon, Sergi Consolato, Kast Richard E, Kanwar Badar A, Bourbeau Jean, Oh Sangsuk, Sohn Mun-Gi, Lee Chul Joong, Coleman Michael D
Science and Research Center, Seoul National University College of Medicine, Seoul, South Korea.
Division of Anatomical Pathology, Children's Hospital of Eastern Ontario (CHEO), University of Ottawa, Ottawa, ON, Canada.
Biomed J. 2025 Apr;48(2):100766. doi: 10.1016/j.bj.2024.100766. Epub 2024 Jul 14.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts between the host and virus and govern induction, resulting in multiorgan impacts. Its pathophysiology involves the followings: 1) the angiotensin-converting enzyme (ACE2) and Toll-like receptor (TLR) pathways: 2) the neuropilin (NRP) pathway: 3) the spike protein pathway. Therefore, it is necessary to block the pathological course with modulating innate lymphoid cells against diverse corona variants in the future.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）在宿主与病毒之间相互作用并控制诱导过程，从而导致多器官影响。其病理生理学涉及以下方面：1）血管紧张素转换酶（ACE2）和Toll样受体（TLR）途径；2）神经纤毛蛋白（NRP）途径；3）刺突蛋白途径。因此，未来有必要通过调节天然淋巴细胞来阻断针对多种冠状病毒变体的病理过程。
