异沙蝇素 A 和 B，两种新型多环不对称二萜二聚体来自：结构阐明、修饰及对 α-葡萄糖苷酶的抑制活性。
Isoxerophilusins A and B, Two Novel Polycyclic Asymmetric Diterpene Dimers from : Structural Elucidation, Modification, and Inhibitory Activities against α-Glucosidase.
机构信息
Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Org Lett. 2024 Jul 26;26(29):6203-6208. doi: 10.1021/acs.orglett.4c02095. Epub 2024 Jul 14.
Isoxerophilusins A () and B (), two unprecedented diterpene heterodimers biogenetically from -atisanes and abietanes, were isolated from the rhizomes of . Their structures were determined by extensive spectroscopic analysis and single-crystal X-ray diffraction. Selective esterification of generated 11 new derivatives. All derivatives showed excellent -glucosidase inhibitory activity in comparison to acarbose. Compounds and demonstrated significant inhibition against -glucosidase with IC values of 4.92 and 3.83 M, respectively.
异沙蚕毒素 A()和 B()，两个前所未有的二萜杂二聚体，来源于-蒎烯和贝壳杉烯，从 Isoxerophilus 属植物的根茎中分离得到。它们的结构通过广泛的光谱分析和单晶 X 射线衍射确定。对 进行选择性酯化得到 11 个新衍生物。与阿卡波糖相比，所有衍生物均显示出优异的 -葡萄糖苷酶抑制活性。化合物和表现出对 -葡萄糖苷酶的显著抑制作用，IC 值分别为 4.92 和 3.83 μM。
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