Shan Wei-Guang, Wu Zhao-Ying, Pang Wei-Wei, Ma Lie-Feng, Ying You-Min, Zhan Zha-Jun
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone: +86-571-88871075; fax: +86-571-88320913).
Chem Biodivers. 2015 Nov;12(11):1718-24. doi: 10.1002/cbdv.201500027.
One new diketopiperazine alkaloid amauromine B (1), along with three known meroterpenoids, austalide B (2), austalides N and O (3 and 4), and two known steroids (5 and 6), was isolated and identified from the culture broth of the fungus Aspergillus terreus 3.05358. Their structures were elucidated by extensive spectroscopic techniques, including 2D-NMR and MS analysis, the absolute configuration of 1 was unambiguously established by single crystal X-ray diffraction analysis. All the isolates were evaluated for their inhibitory effects on α-glucosidase. Amauromine B (1) and austalide N (3) exhibited more potent α-glucosidase inhibitory activities than the positive control acarbose.
从土曲霉3.05358的培养液中分离并鉴定出一种新的二酮哌嗪生物碱阿玛罗明B（1），以及三种已知的半萜类化合物奥司他利德B（2）、奥司他利德N和O（3和4），还有两种已知的甾体化合物（5和6）。通过广泛的光谱技术，包括二维核磁共振和质谱分析阐明了它们的结构，通过单晶X射线衍射分析明确确定了1的绝对构型。评估了所有分离物对α-葡萄糖苷酶的抑制作用。阿玛罗明B（1）和奥司他利德N（3）表现出比阳性对照阿卡波糖更强的α-葡萄糖苷酶抑制活性。
