Hua J, Fan X K, Su J, Chen L L, Lu Y, Hua Y J, Ren H F, Pei P, Sun D J Y, Yu C Q, Lyu J, Zhou J Y, Tao R
School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Department of Non-communicable Chronic Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2024 Jul 10;45(7):914-922. doi: 10.3760/cma.j.cn112338-20231215-00356.
To investigate the association between sleep status and the risk for coronary heart disease in adults in Suzhou. Using the baseline and follow up information of 53 269 local residents aged 30-79 years in China Kadoorie Biobank conducted in Wuzhong District, Suzhou, 51 929 subjects were included in this study after excluding those reporting coronary heart disease, stroke and cancer at the baseline survey. A Cox proportional hazards regression model was used to analyze the association of healthy sleep score (0-3 points) and sleep factors (snoring, insomnia, long sleep duration and nap) with the risk for coronary heart disease. The median follow-up time was 11.12 years, and 1 304 individuals were diagnosed with coronary heart disease during the follow-up. After adjusting for potential confounders, occasional snoring (=1.20, 95%: 1.04-1.38), usual snoring (=1.17, 95%: 1.02-1.33), insomnia disorder (=1.41, 95%: 1.12-1.78), daytime dysfunction (=1.56, 95%: 1.20-2.03) and perennial nap (=1.37, 95%: 1.19-1.59) were associated with increased risk of coronary heart disease. Compared with those with sleep score of 0 - 1 (low sleep quality), the people with sleep score of 3 had reduced risk of coronary heart disease by 26% (=0.74, 95%: 0.63-0.87). Stratified analysis showed that the association of healthy sleep score 3 with risk of coronary heart disease was stronger in low physically active individuals (interaction <0.05). Snoring, insomnia disorders, daytime dysfunction, and perennial napping were all associated with increased risk for coronary heart disease, and keep healthy sleep mode might reduce the risk for coronary heart disease in adults.
旨在研究苏州成年人睡眠状况与冠心病风险之间的关联。利用中国慢性病前瞻性研究项目在苏州吴中区开展的针对53269名30 - 79岁当地居民的基线和随访信息，在排除基线调查时报告患有冠心病、中风和癌症的人群后，本研究纳入了51929名受试者。采用Cox比例风险回归模型分析健康睡眠评分（0 - 3分）以及睡眠因素（打鼾、失眠、睡眠时间过长和午睡）与冠心病风险之间的关联。中位随访时间为11.12年，随访期间有1304人被诊断为冠心病。在调整潜在混杂因素后，偶尔打鼾（=1.20，95%置信区间：1.04 - 1.38）、经常打鼾（=1.17，95%置信区间：1.02 - 1.33）、失眠障碍（=1.41，95%置信区间：1.12 - 1.78）、日间功能障碍（=1.56，95%置信区间：1.20 - 2.03）和常年午睡（=1.37，95%置信区间：1.19 - 1.59）均与冠心病风险增加相关。与睡眠评分为0 - 1分（睡眠质量差）的人群相比，睡眠评分为3分的人群患冠心病的风险降低了26%（=0.74，95%置信区间：0.63 - 0.87）。分层分析显示，健康睡眠评分为3分与冠心病风险之间的关联在身体活动水平较低的个体中更强（交互作用<0.05）。打鼾、失眠障碍、日间功能障碍和常年午睡均与冠心病风险增加相关，保持健康的睡眠模式可能会降低成年人患冠心病的风险。
