Wang H, Zhang Y Q, Yu C Q, Guo Y, Pei P, Chen J S, Chen Z M, Lyu J, Li Liming
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2022 Jul 10;43(7):1002-1009. doi: 10.3760/cma.j.cn112338-20210930-00760.
To analyze the associations between sleep status and the risk for kidney stone in Chinese adults. This study used baseline and long-term follow-up data of China Kadoorie Biobank. After excluding those with self-reporting of diagnosed chronic kidney disease and cancer and those with extreme values of sleep duration at baseline survey, 501 701 participants were included in this study. The information about their sleep status were collected, including insomnia symptoms, daytime sleepiness, nap habit, snoring and sleep duration. The sleep score was constructed based on insomnia symptoms, daytime sleepiness, and sleep duration, ranging from 0 to 3. Cox proportional hazards regression models were used to evaluate the association of sleep status with the risk for kidney stone, including individual sleep factors and combined sleep score. During the follow-up for average (10.7±2.2) years, 12 381 cases of kidney stone were recorded for the first time. Compared with participants without insomnia symptoms, the multivariable-adjusted of kidney stone in those with difficulty falling asleep and waking up early were 1.12 (95%: 1.06-1.18) and 1.06 (95%: 1.00-1.12), respectively. There was no statistically significant association of kidney stone risk with sleeping pill use, daytime sleepiness, nap habit, or snoring. Compared with participants with sleep duration ≥7 hours per day, the of kidney stone in those with sleep duration <7 hours per day was 1.13 (95%: 1.08-1.18). Compared with participants with sleep score of 3 (highest sleep quality), the of kidney stone in those with sleep score of 2, 1, and 0 were 1.08 (95%: 1.03-1.13), 1.16 (95%: 1.10-1.23), and 1.19 (95%: 1.03-1.37), respectively. In China, adults with insomnia symptoms or short sleep duration have increased risk for kidney stone.
分析中国成年人睡眠状况与肾结石风险之间的关联。本研究使用了中国嘉道理生物银行的基线和长期随访数据。在排除那些自我报告患有诊断明确的慢性肾脏病和癌症的人群以及在基线调查中睡眠时长有极端值的人群后，本研究纳入了501701名参与者。收集了他们的睡眠状况信息，包括失眠症状、日间嗜睡、午睡习惯、打鼾和睡眠时长。基于失眠症状、日间嗜睡和睡眠时长构建睡眠评分，范围为0至3。采用Cox比例风险回归模型评估睡眠状况与肾结石风险的关联，包括个体睡眠因素和综合睡眠评分。在平均（10.7±2.2）年的随访期间，首次记录到12381例肾结石病例。与没有失眠症状的参与者相比，入睡困难和早醒者患肾结石的多变量调整后风险分别为1.12（95%置信区间：1.06 - 1.18）和1.06（95%置信区间：1.00 - 1.12）。肾结石风险与使用安眠药、日间嗜睡、午睡习惯或打鼾之间无统计学显著关联。与每天睡眠时长≥7小时的参与者相比，每天睡眠时长<7小时者患肾结石的风险为1.13（95%置信区间：1.08 - 1.18）。与睡眠评分为3（睡眠质量最高）的参与者相比，睡眠评分为2、1和0者患肾结石的风险分别为1.08（95%置信区间：1.03 - 1.13）、1.16（95%置信区间：1.10 - 1.23）和1.19（95%置信区间：1.03 - 1.37）。在中国，有失眠症状或睡眠时长较短的成年人患肾结石的风险增加。
