Maleki Fatemeh, Safarzade Alireza
Departments of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran.
Indian J Endocrinol Metab. 2022 Nov-Dec;26(6):524-529. doi: 10.4103/ijem.ijem_214_22. Epub 2023 Feb 7.
Obesity is associated with a chronic inflammatory condition, which plays an important role in the development of insulin resistance and disorder in appetite regulation. Resistance training (RT) can improve low-grade systemic inflammation caused by obesity by improving body composition. Hence, this study aimed to investigate whether RT with improvement in inflammatory status leads to improvement of metabolic markers and appetite-regulating peptides in obese women.
Sixteen obese and healthy women were randomly divided into RT and control groups. The RT group participated in 8 weeks of RT. Blood samples and anthropometric characteristics were taken before the start of the exercise protocol and 3 days after the last training session. Serum levels of leptin, ghrelin, adiponectin, tumour necrosis factor (TNF-α), fasting glucose, insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) were also measured.
After 8 weeks of training, body weight (BW) and body mass index (BMI) in the control group increased significantly ( < 0.01), but in the training group, anthropometric characteristics remained unchanged. Serum levels of ghrelin and leptin, adiponectin and tumour necrosis factor remained unchanged after 8 weeks of RT. A significant increase in insulin and homeostatic model assessment of insulin resistance levels was observed in the control group ( < 0.05).
It seems that 8 weeks of RT is not enough to induce an anti-inflammatory response and improve body composition and subsequently improve appetite and metabolic markers.
肥胖与慢性炎症状态相关，慢性炎症在胰岛素抵抗的发展及食欲调节紊乱中起重要作用。抗阻训练（RT）可通过改善身体成分来改善肥胖引起的低度全身炎症。因此，本研究旨在调查炎症状态得到改善的抗阻训练是否能改善肥胖女性的代谢指标和食欲调节肽。
16名肥胖且健康的女性被随机分为抗阻训练组和对照组。抗阻训练组参加为期8周的抗阻训练。在运动方案开始前及最后一次训练 session 后3天采集血样和人体测量学特征。还测量了血清瘦素、胃饥饿素、脂联素、肿瘤坏死因子（TNF-α）、空腹血糖、胰岛素水平以及胰岛素抵抗稳态模型评估（HOMA-IR）。
经过8周训练后，对照组的体重（BW）和体重指数（BMI）显著增加（<0.01），但训练组的人体测量学特征保持不变。抗阻训练8周后，血清胃饥饿素和瘦素、脂联素以及肿瘤坏死因子水平保持不变。对照组的胰岛素水平和胰岛素抵抗稳态模型评估水平显著增加（<0.05）。
似乎8周的抗阻训练不足以引发抗炎反应、改善身体成分，进而改善食欲和代谢指标。
