Keshel Tyler E, Coker Robert H
Institute of Arctic Biology, University of Alaska-Fairbanks, Fairbanks, AK, USA.
Institute of Arctic Biology, University of Alaska-Fairbanks, Fairbanks, AK, USA ; Center for Translational Research in Aging and Longevity, Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
J Obes Weight Loss Ther. 2015 Jul;5(Suppl 5). doi: 10.4172/2165-7904.S5-003. Epub 2015 Jul 30.
There is a general perception that increased physical activity will improve glucose homeostasis in all individuals. While this is an attractive concept, this conclusion may be overly simplistic and even misleading. The topic was reviewed extensively over 30 years ago and it was concluded that acute exercise enhances glucose uptake. However, in some cases the chronic influence of interventions utilizing exercise may have little effect on glucose metabolism. Moreover, insulin resistance often returns to near baseline levels within a couple of days following cessation of the exercise bout; leaving the overall effectiveness of the intervention in question. Since improving glucose homeostasis should be the focal endpoint of any intervention designed to mitigate the overwhelming degree of insulin resistance in individuals at risk for metabolic disease, it is essential to evaluate the key components of a successful approach.
人们普遍认为，增加体力活动会改善所有人的葡萄糖稳态。虽然这是一个有吸引力的概念，但这一结论可能过于简单化，甚至具有误导性。30多年前就对该主题进行了广泛的综述，得出的结论是急性运动可增强葡萄糖摄取。然而，在某些情况下，利用运动进行干预的长期影响可能对葡萄糖代谢影响甚微。此外，在运动停止后的几天内，胰岛素抵抗通常会恢复到接近基线水平；这使得该干预措施的整体有效性受到质疑。由于改善葡萄糖稳态应该是任何旨在减轻代谢疾病风险个体中严重胰岛素抵抗程度的干预措施的核心终点，因此评估成功方法的关键组成部分至关重要。
