Li Xiang, Yang Xu, Guo Wei, Li Hao, Sun Weiqing, Lin Xingda, Ma Zuoxin, Li Xuan, Liu Zhe
Department of Pancreatic-Biliary Surgery, The First Hospital of China Medical University Shenyang 110001, Liaoning, China.
Medical Laboratory, Liaoning Province Hospital Shenyang 110001, Liaoning, China.
Am J Cancer Res. 2024 Jun 15;14(6):2695-2713. doi: 10.62347/XLZX8935. eCollection 2024.
Pancreatic cancer is one of the gastrointestinal tumors with the lowest survival rate and the worst prognosis. At the time of diagnosis, the majority of patients have missed the opportunity for radical surgical resection and opt for chemotherapy as their primary treatment choice. And drug resistance emerges during the application of the most widely used chemotherapeutic regimens such as modified FOLFIRINOX regimen, gemcitabine monotherapy or 5-Fluorouracil combination therapy, which further reduces the therapeutic efficacy. Therefore, it is urgent to explore better treatment strategies for pancreatic cancer. In recent years, more and more studies have found that natural products have significant anti-pancreatic cancer properties. In this paper, we reviewed the possible mechanisms by which natural products inhibit the proliferation and invasion of pancreatic cancer cells, including the possible mechanisms of targeting the inhibition of the growth and proliferation regulatory pathways of pancreatic cancer cells, inducing apoptosis and autophagy of pancreatic cancer cells, inhibiting the EMT process of pancreatic cancer cells, and inhibiting the angiogenesis of pancreatic cancer. Meanwhile, natural products have also hindered the progress of their basic and clinical research due to the complexity of their composition and the limitation of biological extraction technology. Further exploration of the specific molecular mechanisms of natural products to inhibit the proliferation and invasion of pancreatic cancer cells, optimization of purification and preparation techniques, and enrichment of basic and clinical trials to verify their efficacy and safety may be the future direction of natural products in the field of anti-pancreatic cancer research.
胰腺癌是生存率最低、预后最差的胃肠道肿瘤之一。在确诊时，大多数患者已错过根治性手术切除的机会，而选择化疗作为主要治疗手段。并且在应用最广泛的化疗方案（如改良FOLFIRINOX方案、吉西他滨单药治疗或5-氟尿嘧啶联合治疗）过程中会出现耐药性，这进一步降低了治疗效果。因此，迫切需要探索更好的胰腺癌治疗策略。近年来，越来越多的研究发现天然产物具有显著的抗胰腺癌特性。本文综述了天然产物抑制胰腺癌细胞增殖和侵袭的可能机制，包括靶向抑制胰腺癌细胞生长和增殖调控途径、诱导胰腺癌细胞凋亡和自噬、抑制胰腺癌细胞的上皮-间质转化过程以及抑制胰腺癌血管生成的可能机制。同时，由于天然产物成分复杂以及生物提取技术的限制，其基础和临床研究进展也受到了阻碍。进一步探索天然产物抑制胰腺癌细胞增殖和侵袭的具体分子机制、优化纯化和制备技术、丰富基础和临床试验以验证其疗效和安全性，可能是天然产物在抗胰腺癌研究领域的未来发展方向。
