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腹膜假黏液瘤:一生的抗争与治愈的希望——一种罕见诊断及文献综述

Pseudomyxoma peritonei: The struggle of a lifetime and the hope of a cure - a rare diagnosis with review of the literature.

作者信息

Askar Ahmet, Arpat Asli, Durgun Vedat

机构信息

Department of General Surgery, Istanbul University Cerrahpasa-Cerrahpasa Faculty of Medicine, Istanbul, Turkiye.

出版信息

North Clin Istanb. 2024 Jun 28;11(3):261-268. doi: 10.14744/nci.2023.50374. eCollection 2024.

DOI:10.14744/nci.2023.50374
PMID:39005750
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11237824/
Abstract

Pseudomyxoma peritonei is a rare pathological condition characterized by mucinous tumor tissue implants on the peritoneal surface. Although the cause of Pseudomyxoma peritonei has been extensively studied, the prevailing agreement is that it stems from mucinous tumors that occur in the ovaries or appendix. The tumor tissue typically remains localized to the peritoneum and does not exhibit extraperitoneal spread. Patients with Pseudomyxoma peritonei may present with symptoms such as abdominal pain, bloating, loss of appetite, and shortness of breath. Computerized Tomography is commonly used for diagnostic purposes. The treatment of Pseudomyxoma peritonei typically involves surgical evacuation of the tumoral tissue, followed by cytoreduction and Hyperthermic Intraperitoneal Chemotherapy. While effective treatment options are available, some patients may require repeated surgeries over an extended period. This paper reports on a case study of a patient with a history of recurrent Pseudomyxoma peritonei, necessitating multiple surgical interventions over a decade. The paper concludes with a review of the relevant literature.

摘要

腹膜假黏液瘤是一种罕见的病理状况,其特征为黏液性肿瘤组织种植于腹膜表面。尽管对腹膜假黏液瘤的病因已进行了广泛研究,但普遍的共识是它起源于卵巢或阑尾发生的黏液性肿瘤。肿瘤组织通常局限于腹膜,不表现为腹膜外扩散。腹膜假黏液瘤患者可能出现腹痛、腹胀、食欲不振和呼吸急促等症状。计算机断层扫描常用于诊断目的。腹膜假黏液瘤的治疗通常包括手术清除肿瘤组织,随后进行肿瘤细胞减灭术和腹腔内热化疗。虽然有有效的治疗方案,但一些患者可能需要在较长时间内反复进行手术。本文报告了一例有复发性腹膜假黏液瘤病史的患者的病例研究,该患者在十年间需要多次手术干预。本文最后对相关文献进行了综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306c/11237824/b77243456d12/NCI-11-261-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306c/11237824/f07ee5195f1c/NCI-11-261-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306c/11237824/a67da0f2775e/NCI-11-261-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306c/11237824/15fc67ff9594/NCI-11-261-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306c/11237824/3f364b99888c/NCI-11-261-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306c/11237824/b77243456d12/NCI-11-261-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306c/11237824/f07ee5195f1c/NCI-11-261-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306c/11237824/a67da0f2775e/NCI-11-261-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306c/11237824/15fc67ff9594/NCI-11-261-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306c/11237824/3f364b99888c/NCI-11-261-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306c/11237824/b77243456d12/NCI-11-261-g005.jpg

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本文引用的文献

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Four cases of pseudomyxoma peritonei with ovarian tumors at our hospital.我院收治的 4 例卵巢肿瘤伴假性黏液瘤病例。
Fukushima J Med Sci. 2023 Apr 5;69(1):57-65. doi: 10.5387/fms.2022-41. Epub 2023 Mar 30.
2
A case of pseudomyxoma peritonei successfully treated with trifluridine/tipiracil (TAS-102) and bevacizumab after palliative debulking surgery.一例假性黏液瘤腹膜病患者,在姑息性肿瘤减灭术后用替氟尿苷/替匹嘧啶(TAS-102)联合贝伐珠单抗治疗获得成功。
Chin Clin Oncol. 2021 Jun;10(3):29. doi: 10.21037/cco-21-2. Epub 2021 Mar 18.
3
Mucinous Appendiceal Adenocarcinoma Penetrated the Quadratus Lumborum Muscle Posteriorly and Presented as Gluteal Abscess Managed Aggressively with Drainage Followed by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Combined with Intraoperative Radiotherapy. a Case Report and Review of the Literature.
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Indian J Surg Oncol. 2020 Sep;11(Suppl 1):128-130. doi: 10.1007/s13193-020-01090-x. Epub 2020 May 21.
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Complete pathological response of high grade appendicular neoplasm induced Pseudomyxoma Peritonei (PMP) after neoadjuvant intra-peritoneal chemotherapy: A case report.新辅助腹腔化疗后高级别阑尾肿瘤诱发腹膜假黏液瘤(PMP)的完全病理缓解:一例报告
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