El-Aziz Gamal Said Abd, Hindi Emad A, Aggad Waheeb S, Alturkistani Hani A, Halawani Mervat M, Alyazidi Anas S
Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Anatomy, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
J Microsc Ultrastruct. 2022 Nov 9;12(2):62-70. doi: 10.4103/jmau.jmau_81_21. eCollection 2024 Apr-Jun.
Cadmium (Cd) is a widely spread environmental pollutant, listed among the unsafe metals due to known toxic effects on multiple organs, including the testes. In this study, we aim to evaluate the potential protectivity of garlic and ginger extracts on Cd-induced damage of the testis in rats.
Fifty-six adult male albino rats were alienated into seven groups; control group, garlic-treated group, and ginger-treated group were given garlic and ginger extracts at doses of 250 mg and 120 mg/kg b.wt/day, Cd-treated group received 8.8 mg/Kg b.wt/day of Cd chloride, and the protected groups were given Cd and co-treated with garlic, ginger, or both extracts. The testes were subjected to different procedures to assess the oxidative status and histopathological changes.
Cd-treated rats showed a significant reduction in the testis weight and morphometric measurements of the seminiferous tubules compared to the control group. Cd administration resulted in a marked drop in the testosterone level and activities of antioxidative enzymes. Moreover, Cd induced histopathological changes in the seminiferous tubules. Co-administration of garlic and ginger extracts with the Cd showed partial improvement in the investigated parameters toward the control figures and improvement in the morphological changes. Co-treating both extracts together and the Cd resulted in complete normalization of these adverse effects of Cd.
These findings indicated that garlic and ginger extracts could ameliorate the harmful effects of Cd on the testis. This effect was more prominent when garlic and ginger extracts were co-administered together with Cd.
镉（Cd）是一种广泛传播的环境污染物，由于其对包括睾丸在内的多个器官具有已知的毒性作用，被列为不安全金属。在本研究中，我们旨在评估大蒜和生姜提取物对镉诱导的大鼠睾丸损伤的潜在保护作用。
将56只成年雄性白化大鼠分为七组；对照组、大蒜处理组和生姜处理组分别以250毫克和120毫克/千克体重/天的剂量给予大蒜和生姜提取物，镉处理组接受8.8毫克/千克体重/天的氯化镉，保护组给予镉并同时用大蒜、生姜或两种提取物进行联合处理。对睾丸进行不同的检测程序以评估氧化状态和组织病理学变化。
与对照组相比，镉处理的大鼠睾丸重量和生精小管的形态学测量值显著降低。给予镉导致睾酮水平和抗氧化酶活性明显下降。此外，镉诱导生精小管出现组织病理学变化。大蒜和生姜提取物与镉联合给药使所研究的参数部分改善至接近对照值，并使形态学变化得到改善。两种提取物与镉共同处理使镉的这些不良反应完全恢复正常。
这些发现表明大蒜和生姜提取物可以减轻镉对睾丸的有害影响。当大蒜和生姜提取物与镉联合给药时，这种效果更为显著。
