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Aging and musculoskeletal health.

作者信息

Tang Tingting

机构信息

Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.

出版信息

J Orthop Translat. 2024 Jun 5;46:A1-A2. doi: 10.1016/j.jot.2024.05.006. eCollection 2024 May.

DOI:10.1016/j.jot.2024.05.006
PMID:39006250
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11245754/
Abstract
摘要

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Metformin prevents mandibular bone loss in a mouse model of accelerated aging by correcting dysregulated AMPK-mTOR signaling and osteoclast differentiation.二甲双胍通过纠正失调的AMPK-mTOR信号传导和破骨细胞分化，预防加速衰老小鼠模型中的下颌骨丢失。
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SPARCL1 promotes chondrocytes extracellular matrix degradation and inflammation in osteoarthritis via TNF/NF-κB pathway.SPARCL1通过TNF/NF-κB途径促进骨关节炎中软骨细胞外基质降解和炎症反应。
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Exosomes from umbilical cord mesenchymal stem cells ameliorate intervertebral disc degeneration via repairing mitochondrial dysfunction.脐带间充质干细胞来源的外泌体通过修复线粒体功能障碍改善椎间盘退变。
J Orthop Translat. 2024 May 27;46:103-115. doi: 10.1016/j.jot.2023.10.004. eCollection 2024 May.
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Effects of physical exercise on neuromuscular junction degeneration during ageing: A systematic review.体育锻炼对衰老过程中神经肌肉接头退化的影响：一项系统综述。
J Orthop Translat. 2024 May 23;46:91-102. doi: 10.1016/j.jot.2024.03.007. eCollection 2024 May.
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YAP maintains cartilage stem/progenitor cell homeostasis in osteoarthritis.YAP维持骨关节炎中软骨干细胞/祖细胞的稳态。
J Orthop Translat. 2024 May 22;46:79-90. doi: 10.1016/j.jot.2024.03.004. eCollection 2024 May.
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HIF-2α/TFR1 mediated iron homeostasis disruption aggravates cartilage endplate degeneration through ferroptotic damage and mtDNA release: A new mechanism of intervertebral disc degeneration.HIF-2α/TFR1介导的铁稳态破坏通过铁死亡损伤和线粒体DNA释放加重软骨终板退变：椎间盘退变的一种新机制
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