硫酸丙二醇甘露聚糖对非增殖性糖尿病视网膜病变的作用。
Effect of propylene glycol mannate sulfate on non-proliferative diabetic retinopathy.
作者信息
Wang Mingming, Song Bangjian, Xu Haining
机构信息
Department of Ophthalmology, Chengyang People's Hospital Qingdao, Shandong, China.
Department of Ophthalmology, Rizhao Central Hospital Rizhao, Shandong, China.
出版信息
Am J Transl Res. 2024 Jun 15;16(6):2509-2516. doi: 10.62347/URTF9525. eCollection 2024.
PURPOSE
To evaluate the effect of propylene glycol mannate sulfate (PGMS) on retinopathy in non-proliferative diabetic patients.
METHODS
Eighty patients (111 eyes) with non-proliferative diabetic retinopathy were selected and retrospectively analyzed. Patients were divided into a control group (40 cases, 56 eyes) and an experimental group (40 cases, 55 eyes) using a random number table method. The control group continued had routine blood glucose management, while the experimental group received PGMS 100 mg additionally TID for 60 days. Changes in visual acuity, fundus conditions including hemorrhage points and exudation in each quadrant, and non-perfusion area were revealed through fundus angiography before and after the treatment period.
RESULTS
After PGMS treatment, the experimental group demonstrated significant improvements compared to the control group in terms of eyesight improvement (=0.002), the macular edema and macular retinal thickness (=0.008). The total clinical efficacy rate of the experimental group was 67.86%, which was higher than 38.18% of the control group (=0.032). Notably, there was a significant reduction in macular hemorrhage and hard extrusion.
CONCLUSION
Oral administration of PGMS is an effective treatment for non-proliferative diabetic retinopathy.
目的
评估硫酸丙二醇甘露聚糖（PGMS）对非增殖性糖尿病患者视网膜病变的影响。
方法
选取80例（111只眼）非增殖性糖尿病视网膜病变患者进行回顾性分析。采用随机数字表法将患者分为对照组（40例，56只眼）和实验组（40例，55只眼）。对照组继续进行常规血糖管理，而实验组额外每日三次接受100mg PGMS治疗，持续60天。通过治疗前后的眼底血管造影揭示视力、眼底情况（包括每个象限的出血点和渗出）以及无灌注区的变化。
结果
PGMS治疗后，实验组在视力改善（=0.002）、黄斑水肿和黄斑视网膜厚度（=0.008）方面与对照组相比有显著改善。实验组的总临床有效率为67.86%，高于对照组的38.18%（=0.032）。值得注意的是，黄斑出血和硬性渗出明显减少。
结论
口服PGMS是治疗非增殖性糖尿病视网膜病变的有效方法。
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