Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Front Endocrinol (Lausanne). 2024 Jun 28;15:1406046. doi: 10.3389/fendo.2024.1406046. eCollection 2024.
Fatty infiltration denotes the anomalous accrual of adipocytes in non-adipose tissue, thereby generating toxic substances with the capacity to impede the ordinary physiological functions of various organs. With aging, the musculoskeletal system undergoes pronounced degenerative alterations, prompting heightened scrutiny regarding the contributory role of fatty infiltration in its pathophysiology. Several studies have demonstrated that fatty infiltration affects the normal metabolism of the musculoskeletal system, leading to substantial tissue damage. Nevertheless, a definitive and universally accepted generalization concerning the comprehensive effects of fatty infiltration on the musculoskeletal system remains elusive. As a result, this review summarizes the characteristics of different types of adipose tissue, the pathological mechanisms associated with fatty infiltration in bone, muscle, and the entirety of the musculoskeletal system, examines relevant clinical diseases, and explores potential therapeutic modalities. This review is intended to give researchers a better understanding of fatty infiltration and to contribute new ideas to the prevention and treatment of clinical musculoskeletal diseases.
脂肪浸润是指脂肪细胞在非脂肪组织中的异常蓄积，从而产生具有阻碍各种器官正常生理功能的毒性物质。随着年龄的增长，骨骼肌肉系统会发生明显的退行性改变，因此需要更加关注脂肪浸润在其病理生理学中的作用。多项研究表明，脂肪浸润会影响骨骼肌肉系统的正常代谢，导致大量组织损伤。然而，脂肪浸润对骨骼肌肉系统的全面影响还没有一个明确和普遍接受的定论。因此，本综述总结了不同类型脂肪组织的特征，以及脂肪浸润在骨骼、肌肉和整个骨骼肌肉系统中相关的病理机制，考察了相关的临床疾病，并探讨了潜在的治疗方法。本综述旨在帮助研究人员更好地了解脂肪浸润，并为临床骨骼肌肉疾病的预防和治疗提供新的思路。
