Binu Aditya John, Mittal Abhishek, Cherian Kripa Elizabeth, Ravi Logesh M, Agarwal Mayank, Alex Anoop George, Kapoor Nitin, Paul Thomas V
Department of Cardiology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Department of Endocrinology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Heart Int. 2024 Jun 25;18(1):51-55. doi: 10.17925/HI.2024.18.1.8. eCollection 2024.
Epidemiological studies have shown an association between coronary artery disease (CAD) and osteoporosis. We studied the prevalence of CAD among postmenopausal women with osteoporosis. Factors that were significantly associated with CAD were also assessed. This was a cross-sectional study conducted over a period of 2 years. Consecutive postmenopausal women aged ≥50 years were recruited. The details of an underlying CAD were obtained. Bone biochemical parameters, bone mineral density and body composition were assessed. A total of 370 postmenopausal women with mean (standard deviation [SD]) ages of 61.6 (6.2) and 60.1 (6.0) years and a body mass index of 25.3 (14.1) kg/m were recruited. Among them, 110 of 370 patients (29.7%) had an underlying CAD and 222 of 370 (60%) had osteoporosis at either the femoral neck or lumbar spine (LS). The odds of CAD among those with osteoporosis were 3.5 (95% confidence interval [CI]: 2.1-5.9). An LS T-score of ≤-2.2 had a sensitivity of 80% and a specificity of 45% in predicting CAD (area under the curve, AUC: 0.736; 95% CI: 0.677-0.795; p<0.001). A femoral neck T-score of ≤-1.9 had a sensitivity of 80% and a specificity of 60% in predicting CAD (AUC: 0.748; 95% CI: 0.696-0.800; p<0.001). On a logistic regression analysis after adjusting for various clinical parameters, femoral neck osteoporosis had the highest odds of CAD. The prevalence of CAD was higher among postmenopausal women with osteoporosis. Femoral neck osteoporosis conferred the highest odds of CAD after adjustment for other clinical factors.
流行病学研究表明冠状动脉疾病（CAD）与骨质疏松症之间存在关联。我们研究了患有骨质疏松症的绝经后女性中CAD的患病率。还评估了与CAD显著相关的因素。这是一项为期2年的横断面研究。招募了年龄≥50岁的连续绝经后女性。获取了潜在CAD的详细信息。评估了骨生化参数、骨密度和身体成分。共招募了370名绝经后女性，平均（标准差[SD]）年龄为61.6（6.2）岁和60.1（6.0）岁，体重指数为25.3（14.1）kg/m。其中，370名患者中有110名（29.7%）患有潜在CAD，370名中有222名（60%）在股骨颈或腰椎（LS）患有骨质疏松症。患有骨质疏松症的人群中CAD的比值比为3.5（95%置信区间[CI]：2.1 - 5.9）。LS的T值≤ - 2.2在预测CAD时的敏感性为80%，特异性为45%（曲线下面积，AUC：0.736；95% CI：0.677 - 0.795；p < 0.001）。股骨颈T值≤ - 1.9在预测CAD时的敏感性为80%，特异性为60%（AUC：0.748；95% CI：0.696 - 0.800；p < 0.001）。在对各种临床参数进行调整后的逻辑回归分析中，股骨颈骨质疏松症患CAD的比值比最高。患有骨质疏松症的绝经后女性中CAD的患病率更高。在对其他临床因素进行调整后，股骨颈骨质疏松症患CAD的几率最高。
