绝经后女性冠状动脉病变严重程度与骨密度的相关性
Association of Severity of Coronary Lesions with Bone Mineral Density in Postmenopausal Women.
作者信息
Xu Rui, Cheng Xin-Chun, Zhang Yuan, Lai Hong-Mei, Yang Hong-Ni
机构信息
Gerontology Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
Department of Cardiology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
出版信息
Arq Bras Cardiol. 2018 Mar;110(3):211-216. doi: 10.5935/abc.20180035.
BACKGROUND
Coronary artery disease (CAD) and osteoporosis (OP) are common diseases in postmenopausal women. In both cross-sectional and longitudinal epidemiologic studies, low bone mass has been related to increased frequency of CAD. However, available data on the relationship between bone mineral density (BMD) and severity of coronary lesions is limited.
OBJECTIVE
To investigate association between the BMD and severity of coronary lesions assessed by Gensini score in postmenopausal women.
METHODS
This study included 122 postmenopausal women who were diagnosed with CAD. These patients were divided into two groups according to the severity of coronary lesions assessed by the Gensini score - patients with mild coronary lesions (Gensini score < 25) and patients with severe coronary lesions (Gensini score ≥ 25). Femoral neck mineral density was measured with dual energy X-ray absorptiometry (DXA).
RESULTS
The study included postmenopausal women aged 64.31 ± 4.71 years, 85 of whom (69.7%) exhibited severe coronary lesions. Participants with severe coronary lesions had a significantly higher T score than did those with mild coronary lesions at the femoral neck (p < 0.05). The mean T-score was -0.84 ± 1.01 in mild coronary lesions group, -1.42 ± 1.39 in severe coronary lesions group (p < 0.05). Multivariable logistic regression analysis showed that osteopenia-osteoporosis at the Femoral neck (odds ratio 2.73; 95% confidence interval 1.06 to 6.13) was associated with an increased risk of developing severe coronary lesions. The multiple regression model showed that T-scores (b = -0.407, SE = 0.151, p=0.007) were the independent predictors of Gensini score.
CONCLUSION
The relationship between severity of coronary lesions and BMD was significant in postmenopausal women. BMD, a low-cost technique involving minimal radiation exposure, widely used for osteoporosis screening, is a promising marker of severity of coronary lesions.
背景
冠状动脉疾病（CAD）和骨质疏松症（OP）是绝经后女性的常见疾病。在横断面和纵向流行病学研究中，低骨量与CAD发病率增加有关。然而，关于骨密度（BMD）与冠状动脉病变严重程度之间关系的现有数据有限。
目的
探讨绝经后女性骨密度与通过Gensini评分评估的冠状动脉病变严重程度之间的关联。
方法
本研究纳入了122例诊断为CAD的绝经后女性。根据Gensini评分评估的冠状动脉病变严重程度，将这些患者分为两组——轻度冠状动脉病变患者（Gensini评分<25）和重度冠状动脉病变患者（Gensini评分≥25）。采用双能X线吸收法（DXA）测量股骨颈骨密度。
结果
该研究纳入了年龄为64.31±4.71岁的绝经后女性，其中8名（69.7%）表现为重度冠状动脉病变。重度冠状动脉病变参与者的股骨颈T评分显著高于轻度冠状动脉病变参与者（p<0.05）。轻度冠状动脉病变组的平均T评分为-0.84±1.01，重度冠状动脉病变组为-1.42±1.39（p<0.05）。多变量逻辑回归分析显示，股骨颈骨质减少-骨质疏松（比值比2.73；95%置信区间1.06至6.13）与发生重度冠状动脉病变的风险增加相关。多元回归模型显示，T评分（b=-0.407，SE=0.151，p=0.007）是Gensini评分的独立预测因子。
结论
绝经后女性冠状动脉病变严重程度与骨密度之间的关系显著。骨密度是一种低成本技术，辐射暴露极少，广泛用于骨质疏松症筛查，是冠状动脉病变严重程度的一个有前景的标志物。
Zotero 插件