Eekers Danielle B P, Zegers Catharina M L, Ahmed Kamran A, Amelio Dante, Gupta Tejpal, Harrabi Semi Ben, Kazda Tomas, Scartoni Daniele, Seidel Clemens, Shih Helen A, Minniti Giuseppe
Department of Radiation Oncology (Maastro), Maastricht University Medical Center, GROW-School for Oncology and Reproduction, Maastricht, The Netherlands.
Departments of Oncologic Sciences, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.
Neurooncol Pract. 2024 Apr 29;11(4):369-382. doi: 10.1093/nop/npae040. eCollection 2024 Aug.
Radiation therapy (RT) plays a fundamental role in the treatment of malignant and benign brain tumors. Current state-of-the-art photon- and proton-based RT combines more conformal dose distribution of target volumes and accurate dose delivery while limiting the adverse radiation effects. PubMed was systematically searched from from 2000 to October 2023 to identify studies reporting outcomes related to treatment of central nervous system (CNS)/skull base tumors with PT in adults. Several studies have demonstrated that proton therapy (PT) provides a reduced dose to healthy brain parenchyma compared with photon-based (xRT) radiation techniques. However, whether dosimetric advantages translate into superior clinical outcomes for different adult brain tumors remains an open question. This review aims at critically reviewing the recent studies on PT in adult patients with brain tumors, including glioma, meningiomas, and chordomas, to explore its potential benefits compared with xRT.
放射治疗（RT）在恶性和良性脑肿瘤的治疗中发挥着重要作用。当前基于光子和质子的先进放射治疗结合了更适形的靶区剂量分布和精确的剂量输送，同时限制了不良放射效应。对2000年至2023年10月期间的PubMed进行了系统检索，以确定报告成人中枢神经系统（CNS）/颅底肿瘤质子治疗（PT）相关治疗结果的研究。多项研究表明，与基于光子的（xRT）放射技术相比，质子治疗（PT）可减少对健康脑实质的剂量。然而，剂量学优势是否能转化为不同成人脑肿瘤更好的临床结果仍是一个悬而未决的问题。本综述旨在批判性地回顾近期关于成人脑肿瘤患者（包括胶质瘤、脑膜瘤和脊索瘤）质子治疗的研究，以探讨其与xRT相比的潜在益处。
