Giannone L, Johnson D H, Grosh W W, Davis B W, Marangos P J, Greco F A
Med Pediatr Oncol. 1985;13(6):357-62. doi: 10.1002/mpo.2950130611.
Three patients with widely disseminated Merkel cell tumors of the skin are presented. In all three cases, neuron-specific enolase (NSE) was demonstrated in neoplastic tissue by immunohistochemical staining, and serum NSE levels were also elevated in all three patients. Serum NSE may prove to be a useful tumor marker in this and other malignancies of neuroendocrine origin.