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揭开 cherubism(家族性颌骨多囊病)之谜:审视典型的“眼睛向上”现象。

Unraveling Cherubism: Examining the Classical "Eye to Heaven" Phenomenon.

作者信息

Sonpal Parmarth M, Mundada Bhushan P, Bhola Nitin, Gupta Chetan, Dodal Ketan

机构信息

Oral and Maxillofacial Surgery, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

出版信息

Cureus. 2024 Jun 12;16(6):e62277. doi: 10.7759/cureus.62277. eCollection 2024 Jun.

DOI:10.7759/cureus.62277
PMID:39006690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11246183/
Abstract

Cherubism, an infrequent disorder with paramount autosomal importance, predominantly targets the mandible, with occasional involvement of the maxilla. Manifesting in childhood, it typically improves over time but never fully resolves in adulthood. Clinically, it presents as a uniform enlargement of the bones, and when the upper jaw is involved, it can create a cherub-like appearance with exposure to the sclera. As the volume grows, it can cause symptoms such as dental misalignment, delayed tooth eruption, speech difficulties, and tooth loss, in addition to psychological and cosmetic effects that require medical attention. The disorder progresses naturally in youngsters, exhibiting phases of expansion, stabilization, and regression. Cherubism initially is encountered in early childhood, reaches its peak during early years, balances out around puberty, and then steadily recedes after that. We describe the example of a male patient, age 20, who sought correction due to worries about his appearance. He had a bilateral mandibular angle and malar edema. The patient's aesthetic discontent was satisfactorily resolved with surgical intervention, and further pharmaceutical therapy was implemented during follow-up visits.

摘要

cherubism是一种罕见的具有重要常染色体意义的疾病,主要累及下颌骨,上颌骨偶尔受累。它在儿童期发病,通常会随着时间推移有所改善,但在成年期不会完全消退。临床上,它表现为骨骼均匀增大,当上颌骨受累时,会因巩膜外露而呈现出小天使般的面容。随着体积增大,除了需要医疗关注的心理和美容影响外,还会导致牙齿排列不齐、牙齿萌出延迟、言语困难和牙齿脱落等症状。这种疾病在青少年中自然发展,呈现出扩张、稳定和消退阶段。 cherubism最初在幼儿期出现,在早年达到高峰,在青春期左右趋于平稳,之后逐渐消退。我们描述了一位20岁男性患者的病例,他因担心自己的外貌而寻求矫正。他双侧下颌角和颧骨有肿胀。通过手术干预,患者的美学不满得到了令人满意的解决,随访期间还实施了进一步的药物治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be69/11246183/4537027744fa/cureus-0016-00000062277-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be69/11246183/1ecd6a03d8ca/cureus-0016-00000062277-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be69/11246183/abe6ae3ce6b5/cureus-0016-00000062277-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be69/11246183/aab7b9a1e1f8/cureus-0016-00000062277-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be69/11246183/4537027744fa/cureus-0016-00000062277-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be69/11246183/1ecd6a03d8ca/cureus-0016-00000062277-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be69/11246183/abe6ae3ce6b5/cureus-0016-00000062277-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be69/11246183/aab7b9a1e1f8/cureus-0016-00000062277-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be69/11246183/4537027744fa/cureus-0016-00000062277-i04.jpg

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