Kim Hye Jun, Jeong Seogsong, Song Jihun, Park Sun Jae, Park Young Jun, Oh Yun Hwan, Jung Jaehun, Park Sang Min
Department of Biomedical Sciences Seoul National University College of Medicine Seoul South Korea.
Department of Biomedical Informatics Korea University College of Medicine Seoul South Korea.
MedComm (2020). 2024 Jul 14;5(7):e655. doi: 10.1002/mco2.655. eCollection 2024 Jul.
Recent studies elucidate that coronavirus disease 2019 (COVID-19) patients may face a higher risk of cardiovascular complications. This study aimed to evaluate association of COVID-19 with the risk of pulmonary embolism (PE) or deep vein thrombosis (DVT). This nationwide population-based retrospective cohort study included Korean adult citizens between January 2021 and March 2022 from the Korea Disease Control and Prevention Agency COVID-19 National Health Insurance Service cohort. The Fine and Gray's regression with all-cause death as a competing event was adopted to evaluate PE and DVT risks after COVID-19. This study included a total of 1,601,835 COVID-19 patients and 14,011,285 matched individuals without COVID-19. The risk of PE (adjusted hazard ratio [aHR], 6.25; 95% confidence interval [CI], 3.67-10.66; < 0.001) and DVT (aHR, 3.05; 95% CI, 1.75-5.29; < 0.001) was higher in COVID-19 group in individuals without complete COVID-19 vaccination. In addition, individuals with complete COVID-19 vaccination still had a higher risk of COVID-19-related PE (aHR, 1.48; 95% CI, 1.15-1.88; < 0.001). However, COVID-19 was not a significant risk factor for DVT among those with complete COVID-19 vaccination. COVID-19 was identified as an independent factor that elevated PE and DVT risks, especially for individuals without complete COVID-19 vaccination.
近期研究表明，2019冠状病毒病（COVID-19）患者可能面临更高的心血管并发症风险。本研究旨在评估COVID-19与肺栓塞（PE）或深静脉血栓形成（DVT）风险之间的关联。这项基于全国人口的回顾性队列研究纳入了2021年1月至2022年3月期间来自韩国疾病控制与预防机构COVID-19国民健康保险服务队列的韩国成年公民。采用以全因死亡作为竞争事件的Fine和Gray回归模型来评估COVID-19后发生PE和DVT的风险。本研究共纳入了1,601,835例COVID-19患者和14,011,285例匹配的未感染COVID-19的个体。在未完成COVID-19全程接种的个体中，COVID-19组发生PE的风险（调整后风险比[aHR]，6.25；95%置信区间[CI]，3.67 - 10.66；<0.001）和DVT的风险（aHR，3.05；95%CI，1.75 - 5.29；<0.001）更高。此外，完成COVID-19全程接种的个体发生与COVID-19相关PE的风险仍然较高（aHR，1.48；95%CI，1.15 - 1.88；<0.001）。然而，在完成COVID-19全程接种的个体中，COVID-19并非DVT的显著风险因素。COVID-19被确定为增加PE和DVT风险的独立因素，尤其是对于未完成COVID-19全程接种的个体。
