Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Institute of Ophthalmology, Capital Medical University, Beijing, China.
Int J Med Sci. 2024 Jun 11;21(9):1604-1611. doi: 10.7150/ijms.94677. eCollection 2024.
To investigate morphological and hemodynamic characteristics of the ophthalmic artery (OA) in patients with white matter hyperintensity (WMH), and the association of the presence and severity of WMH with OA characteristics. This cross-sectional study included 44 eyes of 25 patients with WMH and 38 eyes of 19 controls. The Fazekas scale was adopted as criteria for evaluating the severity of white matter hyperintensities. The morphological characteristics of the OA were measured on the basis of three-dimensional reconstruction. The hemodynamic parameters of the OA were calculated using computational fluid dynamics simulations. Compared with the control group, the diameter (16.0±0.27 mm vs. 1.71±0.18 mm, =0.029), median blood flow velocity (0.12 m/s vs. 0.22 m/s, <0.001), mass flow ratio (2.16% vs. 3.94%, =0.012) and wall shear stress (2.65 Pa vs. 9.31 Pa, <0.001) of the OA in patients with WMH were significantly decreased. After adjusting for confounding factors, the diameter, blood flow velocity, wall shear stress, and mass flow ratio of the OA were significantly associated with the presence of WMH. Male sex and high low-density protein level were associated with moderate-to-severe total WMH, and smoking was associated with the moderate-to-severe periventricular WMH. The diameter, blood flow velocity, mass flow ratio, and wall shear stress of the OA were independently associated with the presence of WMH. Atherosclerosis might be involved in the common mechanism of the occurrence of WMH and the OA changes.
为了研究脑白质高信号（WMH）患者眼动脉（OA）的形态和血流动力学特征，以及 WMH 的存在及其严重程度与 OA 特征之间的关系。本横断面研究纳入了 25 例 WMH 患者的 44 只眼和 19 例对照者的 38 只眼。采用 Fazekas 量表评估脑白质高信号的严重程度。基于三维重建测量 OA 的形态特征。利用计算流体动力学模拟计算 OA 的血流动力学参数。与对照组相比，WMH 患者的 OA 直径（16.0±0.27mm 比 1.71±0.18mm，=0.029）、平均血流速度（0.12m/s 比 0.22m/s，<0.001）、质量流量比（2.16%比 3.94%，=0.012）和壁面切应力（2.65Pa 比 9.31Pa，<0.001）均显著降低。校正混杂因素后，OA 的直径、血流速度、壁面切应力和质量流量比与 WMH 的存在显著相关。男性和高低密度脂蛋白水平与中重度总 WMH 相关，吸烟与中重度脑室周围 WMH 相关。OA 的直径、血流速度、质量流量比和壁面切应力与 WMH 的存在独立相关。动脉粥样硬化可能参与了 WMH 发生和 OA 改变的共同机制。
