Yin Yaqi, Fan Chen, Cheng Linru, Shan Yuwei
School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China.
Food Chem X. 2024 Jun 13;23:101555. doi: 10.1016/j.fochx.2024.101555. eCollection 2024 Oct 30.
In this study, a convenient and effective method for determination of perfluoroalkyl substances (PFASs) in infant formula was developed based on a novel dispersive solid-phase extraction using deep eutectic solvent-functionalized amorphous UiO-66 (DES/aUiO-66) as sorbent. The synthesis of materials could be achieved without the use of complex and environmentally unfriendly procedures. Parameters were systematically investigated to establish a simple, fast, and efficient green pretreatment method. The method demonstrated high sensitivity, good precision, a detection limit of 0.330-0.529 ng·kg, and low matrix effects (< 12.8%). The mechanism for this material was elucidated by ab initio molecular dynamics (AIMD) simulations and quantum chemistry calculations. The presence of massive pore structures and collectively synergistic binding sites facilitated affinity adsorption toward PFASs. Finally, this method was applied to the monitoring of PFASs in 10 actual milk powder samples. This groundbreaking approach opens new possibilities for the advancement of analytical techniques and food safety monitoring.
在本研究中，基于一种新型的分散固相萃取方法，开发了一种便捷有效的测定婴儿配方奶粉中全氟烷基物质（PFASs）的方法，该方法使用深共熔溶剂功能化的非晶态UiO-66（DES/aUiO-66）作为吸附剂。材料的合成无需使用复杂且对环境不友好的程序。系统地研究了各项参数，以建立一种简单、快速且高效的绿色预处理方法。该方法具有高灵敏度、良好的精密度，检测限为0.330 - 0.529 ng·kg，且基质效应低（< 12.8%）。通过从头算分子动力学（AIMD）模拟和量子化学计算阐明了该材料的作用机制。大量孔结构和协同结合位点的存在促进了对PFASs的亲和吸附。最后，该方法应用于10个实际奶粉样品中PFASs的监测。这种开创性的方法为分析技术的进步和食品安全监测开辟了新的可能性。
