Fan Chen, Wang Huijun, Liu Yang, Cao Xueli
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, 100048, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, 100048, China.
Talanta. 2021 Jun 1;228:122214. doi: 10.1016/j.talanta.2021.122214. Epub 2021 Feb 17.
Perfluoroalkyl substances (PFASs) have been identified as global pollutants and raise considerable food safety concerns. However, the development of an analytical method with satisfied pretreatment performance for PFASs with varying alkyl chain length in the fatty samples remains a challenge. We describe herein the preparation of superparamagnetic nanofluid, based on a new choline chloride/1-(o-tolyl)biguanide deep eutectic solvent (DES) system, for direct extraction of perfluoroalkyl carboxylic acids from edible oils. Target PFASs, especially the short-chain one, all possessed high recoveries (90-109% with intra-day and inter-day precision below 10%). This was achieved by adjusting the constituent ratio of DES for balancing the anion-exchange (electrostatic) interactions and hydrogen-bond interactions. Employing the prepared nanofluid in magnetic microextraction, followed by high-resolution mass spectrum analysis, resulted in a rapid (15 min for pretreatment), simple, sensitive (detection limit: 0.3-1.6 pg g), and efficient method for the enrichment and determination of trace PFASs. Furthermore, the introducing of N-H⋯F weak force increased the pretreatment selectivity to effectively reduce the matrix effect. At the end of the study, the proposed methodology was successfully applied to the analysis of target analytes in real samples.
全氟烷基物质（PFASs）已被确认为全球污染物，并引发了相当大的食品安全担忧。然而，开发一种对脂肪样品中具有不同烷基链长度的PFASs具有令人满意的预处理性能的分析方法仍然是一个挑战。我们在此描述了基于一种新型氯化胆碱/1-（邻甲苯基）双胍低共熔溶剂（DES）体系制备的超顺磁性纳米流体，用于从食用油中直接萃取全氟烷基羧酸。目标PFASs，尤其是短链PFASs，回收率均很高（日内和日间精密度低于10%，回收率为90 - 109%）。这是通过调整DES的组成比例来平衡阴离子交换（静电）相互作用和氢键相互作用实现的。将制备的纳米流体用于磁性微萃取，随后进行高分辨率质谱分析，得到了一种快速（预处理15分钟）、简单、灵敏（检测限：0.3 - 1.6 pg/g）且高效的痕量PFASs富集和测定方法。此外，引入N-H⋯F弱作用力提高了预处理的选择性，有效降低了基质效应。在研究结束时，所提出的方法成功应用于实际样品中目标分析物的分析。
