2019-2021 年德国三分之一兽医诊所的犬猫临床样本中耐甲氧西林金黄色葡萄球菌的流行率。
Prevalence of MRSA in canine and feline clinical samples from one-third of veterinary practices in Germany from 2019-2021.
机构信息
Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Koserstraße 20, Berlin 14195, Germany.
Institute of Veterinary Epidemiology and Biostatistics, School of Veterinary Medicine, Freie Universität Berlin, Königsweg 67, Berlin 14163, Germany.
出版信息
J Antimicrob Chemother. 2024 Sep 3;79(9):2273-2280. doi: 10.1093/jac/dkae225.
BACKGROUND
MRSA is a major contributor to AMR-related deaths. The WHO's global action plan emphasizes a One Health approach, acknowledging the connection between humans and their companion animals. It is agreed on that comprehensive AMR surveillance is needed.
OBJECTIVES
This study provides a large-scale overview of MRSA occurrence in cats and dogs in Germany, serving as a foundation for continuous surveillance.
METHODS
The study analysed all results of canine and feline bacterial diagnostic samples from a large laboratory, encompassing samples received from veterinary practices between January 2019 and December 2021. MRSA prevalence between host species, sample types and geographical distribution were compared. Additionally, data were contrasted with human MRSA surveillance data from Germany.
RESULTS
Samples originated from 3491 German veterinary practices, representing 33.1% of practices and clinics nationally. Bacterial examination results from 175 171 samples were analysed, identifying S. aureus in 5526 of these samples (3.2% isolation rate). S. aureus in clinical samples was more prevalent in cats (5.6%) than dogs (2.0%). Methicillin resistance was found in 17.8% of S. aureus samples and was higher in dogs (20.4%, 95%CI 18.9-22.0) than cats (15.6%, 95%CI 14.3-17.0). The highest MRSA prevalence was found in canine wound samples (32%), compared to skin/soft tissue, respiratory tract and other (<23% respectively).
CONCLUSION
The study reveals a 17.8% MRSA prevalence, which is higher than the human outpatient MRSA prevalence (5.4%). Restriction and regulation of veterinary antibiotic use should be validated with AMR surveillance. Our study shows that this is feasible in companion animals with significant coverage.
背景
耐甲氧西林金黄色葡萄球菌（MRSA）是导致与抗生素耐药性相关的死亡的主要因素之一。世界卫生组织（WHO）的全球行动计划强调了一种“同一健康”方法，承认人类与其伴侣动物之间存在联系。人们一致认为需要进行全面的抗生素耐药性监测。
目的
本研究提供了德国猫和狗中耐甲氧西林金黄色葡萄球菌发生情况的大规模概述，为持续监测奠定了基础。
方法
该研究分析了一家大型实验室收到的所有犬和猫细菌诊断样本的结果，这些样本来自 2019 年 1 月至 2021 年 12 月期间兽医诊所的样本。比较了宿主物种、样本类型和地理分布之间的耐甲氧西林金黄色葡萄球菌流行率。此外，还将数据与德国人类耐甲氧西林金黄色葡萄球菌监测数据进行了对比。
结果
样本来自德国 3491 家兽医诊所，占全国诊所和诊所的 33.1%。对 175171 个样本的细菌检测结果进行了分析，在其中 5526 个样本中发现了金黄色葡萄球菌（分离率为 3.2%）。临床样本中金黄色葡萄球菌在猫中的流行率（5.6%）高于狗（2.0%）。在金黄色葡萄球菌样本中发现了 17.8%的耐甲氧西林金黄色葡萄球菌，狗（20.4%，95%CI 18.9-22.0）中的耐甲氧西林金黄色葡萄球菌比例高于猫（15.6%，95%CI 14.3-17.0）。在犬的伤口样本中发现了最高的耐甲氧西林金黄色葡萄球菌流行率（32%），而在皮肤/软组织、呼吸道和其他部位的流行率较低（分别为<23%）。
结论
本研究发现耐甲氧西林金黄色葡萄球菌的流行率为 17.8%，高于人类门诊耐甲氧西林金黄色葡萄球菌的流行率（5.4%）。应通过抗生素耐药性监测来验证兽医抗生素使用的限制和监管。我们的研究表明，在具有显著覆盖范围的伴侣动物中，这是可行的。
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