Feuer Leonie, Frenzer Stefanie Katharina, Merle Roswitha, Bäumer Wolfgang, Lübke-Becker Antina, Klein Babette, Bartel Alexander
Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Koserstraße 20, 14195 Berlin, Germany.
Institute of Veterinary Epidemiology and Biostatistics, School of Veterinary Medicine, Freie Universität Berlin, Königsweg 67, 14163 Berlin, Germany.
Antibiotics (Basel). 2024 Jul 17;13(7):660. doi: 10.3390/antibiotics13070660.
The emergence of methicillin-resistant (MRSP) presents a significant public health concern globally, particularly within veterinary medicine. MRSP's resistance to multiple antibiotics is limiting treatment options and potentially leading to severe infections in companion animals. This study aimed to understand antimicrobial resistance in dogs and cats, focusing on MRSP resistance patterns and its prevalence in Germany. We analyzed results of bacterial diagnostic samples from canines and felines, sourced from a German veterinary diagnostic microbiology laboratory between 2019 and 2021. This dataset included samples from 3491 veterinary practices, covering 33.1% of veterinary practices and clinics in Germany. MRSP rates were detailed by host species, sample types and co-resistance patterns. Analysis of 175,171 bacterial examination results revealed in 44,880 samples, yielding a 25.6% isolation rate. was more prevalent in dogs (35.0%) than cats (3.6%). Methicillin resistance was found in 7.5% of all isolates. MRSP prevalence was higher in feline samples (16.1%, 95% CI 14.4-17.8) compared to canine samples (7.1%, 95% CI 6.8-7.0). showed high resistance rates to ampicillin (cats: 48.6%, dogs: 67.6%) and clindamycin (cats: 37.2%, dogs: 32.7%), while MRSP exhibited high co-resistance to clindamycin (cats: 82.8%, dogs: 85.4%) and sulfamethoxazole + trimethoprim (cats: 66.4%, dogs: 66.2%). Our study revealed distinct resistance patterns of MRSP in cats compared to dogs, highlighting the need for tailored treatment approaches and the importance of antimicrobial resistance surveillance.
耐甲氧西林金黄色葡萄球菌（MRSP）的出现是全球重大的公共卫生问题，在兽医学领域尤为如此。MRSP对多种抗生素的耐药性限制了治疗选择，并可能导致伴侣动物发生严重感染。本研究旨在了解犬猫的抗菌药物耐药性，重点关注德国MRSP的耐药模式及其流行情况。我们分析了来自德国兽医诊断微生物实验室2019年至2021年期间犬科和猫科动物的细菌诊断样本结果。该数据集包括来自3491家兽医诊所的样本，覆盖德国33.1%的兽医诊所。按宿主物种、样本类型和共同耐药模式详细列出了MRSP发生率。对175171份细菌检测结果的分析显示，在44880份样本中，分离率为25.6%。在犬中（35.0%）比猫中（3.6%）更普遍。在所有分离株中，7.5%发现有耐甲氧西林情况。与犬样本（7.1%，95%可信区间6.8 - 7.0）相比，猫样本中MRSP流行率更高（16.1%，95%可信区间14.4 - 17.8）。对氨苄西林显示出高耐药率（猫：48.6%，犬：67.6%）和对克林霉素（猫：37.2%，犬：32.7%），而MRSP对克林霉素（猫：82.8%，犬：85.4%）和磺胺甲恶唑 +甲氧苄啶（猫：66.4%，犬：66.2%）表现出高共同耐药性。我们的研究揭示了与犬相比猫中MRSP不同的耐药模式，突出了需要定制治疗方法以及抗菌药物耐药性监测的重要性。
