Li Hui, Lin Ze, Ouyang Lizhi, Lin Chuanlu, Zeng Ruiyin, Liu Guohui, Zhou Wenjuan
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.
J Liposome Res. 2025 Mar;35(1):76-85. doi: 10.1080/08982104.2024.2378962. Epub 2024 Jul 15.
Diabetic wound is one of the most challenge in healthcare, requiring innovative approaches to promote efficient healing. In recent years, lipid nanoparticle-based drug delivery systems have emerged as a promising strategy for enhancing diabetic wound repair by stimulating angiogenesis. These nanoparticles offer unique advantages, including improved drug stability, targeted delivery, and controlled release, making them promising in enhancing the formation of new blood vessels. In this review, we summarize the emerging advances in the utilization of lipid nanoparticles to deliver angiogenic agents and promote angiogenesis in diabetic wounds. Furthermore, we provide an in-depth exploration of key aspects, including the intricate design and fabrication of lipid nanoparticles, their underlying mechanisms of action, and a comprehensive overview of preclinical studies. Moreover, we address crucial considerations pertaining to safety and the translation of these innovative systems into clinical practice. By synthesizing and analyzing the available knowledge, our review offers valuable insights into the future prospects and challenges associated with utilizing the potential of lipid nanoparticle-based drug delivery systems for promoting robust angiogenesis in the intricate process of diabetic wound healing.
糖尿病伤口是医疗保健领域最具挑战性的问题之一，需要创新方法来促进有效愈合。近年来，基于脂质纳米颗粒的药物递送系统已成为一种有前景的策略，可通过刺激血管生成来增强糖尿病伤口修复。这些纳米颗粒具有独特的优势，包括提高药物稳定性、靶向递送和控释，使其在促进新血管形成方面具有潜力。在本综述中，我们总结了利用脂质纳米颗粒递送血管生成剂并促进糖尿病伤口血管生成的新进展。此外，我们深入探讨了关键方面，包括脂质纳米颗粒的复杂设计和制备、其潜在作用机制以及临床前研究的全面概述。此外，我们还讨论了与安全性以及将这些创新系统转化为临床实践相关的关键考虑因素。通过综合和分析现有知识，我们的综述为利用基于脂质纳米颗粒的药物递送系统在复杂的糖尿病伤口愈合过程中促进强大的血管生成的未来前景和挑战提供了有价值的见解。
