药师主导的干预对前列腺癌疾病认知的影响。

Impact of a pharmacist-led intervention on prostate cancer illness perception.

机构信息

Department of Clinical Pharmacy and Public Health, Faculty of Pharmacy, University of Calabar, Calabar, Cross River State, Nigeria.

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Benin, Benin City, Edo State, Nigeria.

出版信息

Am J Health Syst Pharm. 2024 Nov 22;81(23):e751-e759. doi: 10.1093/ajhp/zxae193.

DOI:10.1093/ajhp/zxae193

PMID:39007878

Abstract

PURPOSE

Illness perception (IP) significantly determines illness outcomes. This study determined the impact of a pharmacist educational intervention on IP and the predictors of IP in patients with prostate cancer (PCa).

METHODS

Using a brief IP questionnaire, an interventional study of patients with PCa was conducted in all cancer reference hospitals in one Nigerian state. After a pre-post assessment of patients' IP, descriptive and inferential statistical analyses were performed. The impact of pharmacists' intervention on IP was determined by paired-sample statistics and correlation analysis at the 95% CI. Relationships and predictors of IP were determined using Kendall's tau-b (τb), likelihood ratio, and F tests of equality of means, respectively. P < 0.05 was considered statistically significant.

RESULTS

Pharmacists' educational intervention significantly improved IP (SEM, 0.13; r = 0.875; P < 0.0001) among the 200 participants. The analyses also showed a significant paired sample difference (2.662; SEM, 0.06; 95%CI, 2.536-2.788; t = 41.69; df = 199; P < 0.0001). All subscales of patients' IP significantly improved except for illness consequences (P = 0.173) and identity (mean [SD], 4.40 [3.730] in both pre- and postintervention assessments). Pre- and postintervention assessments showed a significant negative relationship of IP with age (τb = -110 [P = 0.040] and τb = -14 [P = 0.021], respectively), Gleason score (τb = -0.125 [P = 0.021] and τb = -0.124 [P=0.012], respectively), and age at diagnosis (τb = -0.103 [P = 0.036] post intervention). IP was significantly dependent on the drug therapy (df = 8; mean square [M] = 6.292; F = 2.825; P = 0.006), alcohol intake (df = 1; M = 9.608; F = 4.082; P = 0.045) and Gleason score (df = 9; M = 6.706; F = 3.068; P = 0.002).

CONCLUSION

Patients' IP significantly improved after pharmacists' educational intervention. Predictors of IP were drug therapies, alcohol use and Gleason score. Findings can be extrapolated in clinical settings to improve treatment outcomes.

摘要

目的

疾病感知（IP）对疾病结局有重要影响。本研究旨在确定药剂师教育干预对前列腺癌（PCa）患者 IP 的影响，并确定 IP 的预测因素。

方法

在尼日利亚一个州的所有癌症参考医院，使用简短的 IP 问卷对 PCa 患者进行干预研究。在对患者的 IP 进行前后评估后，进行描述性和推理统计分析。通过配对样本统计和 95%置信区间的相关分析，确定药剂师干预对 IP 的影响。使用 Kendall's tau-b（τb）、似然比和 F 检验分别确定 IP 的关系和预测因素。P<0.05 被认为具有统计学意义。

结果

药剂师的教育干预显著改善了 200 名参与者的 IP（SEM，0.13；r=0.875；P<0.0001）。分析还显示，配对样本差异显著（2.662；SEM，0.06；95%CI，2.536-2.788；t=41.69；df=199；P<0.0001）。除疾病后果（P=0.173）和身份（预干预和后干预评估的平均值[SD]分别为 4.40[3.730]）外，患者 IP 的所有亚量表均显著改善。预干预和后干预评估显示，IP 与年龄（τb=-110[P=0.040]和τb=-14[P=0.021]）、Gleason 评分（τb=-0.125[P=0.021]和τb=-0.124[P=0.012]）和诊断时年龄（τb=-0.103[P=0.036]后干预）呈显著负相关。IP 显著依赖于药物治疗（df=8；均方[M]=6.292；F=2.825；P=0.006）、酒精摄入（df=1；M=9.608；F=4.082；P=0.045）和 Gleason 评分（df=9；M=6.706；F=3.068；P=0.002）。