Killam E K
Fed Proc. 1979 Sep;38(10):2429-33.
The inborn seizure response of Papio papio to intermittent light stimulation has been reviewed as a model of human epilepsy. The electrographic and clinical features have been described and useful methodology has been outlined. A diurnal cyclicity in seizure responsiveness has been described with greatest seizure severity at 8 AM in parallel with a rise in urinary output of cortisol. Hormonal influences on the seizure response have been described for ethinyl estradiol, thyroxin, and triiodothyronine. Evidence regarding neurotransmitter involvement has been reviewed. Data regarding use of the animal for anticonvulsant testing in single and chronic doses has been discussed. Particular advantages of the model for study of age-related drug effects and the assessment of the effects of chronically administered anticonvulsant agents on learning and memory have been described.
豚尾狒狒对间歇性光刺激的先天性癫痫反应已被作为人类癫痫的一种模型进行了综述。已描述了其脑电图和临床特征，并概述了有用的方法。已描述了癫痫反应的昼夜周期性，上午8点癫痫严重程度最高，同时皮质醇尿量增加。已描述了乙炔雌二醇、甲状腺素和三碘甲状腺原氨酸对癫痫反应的激素影响。已综述了有关神经递质参与的证据。已讨论了关于该动物用于单剂量和慢性剂量抗惊厥测试的数据。已描述了该模型在研究年龄相关药物效应以及评估长期给予抗惊厥药物对学习和记忆的影响方面的特殊优势。
