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用一种针对烟碱型胆碱能受体α亚基的单克隆抗体对大鼠下丘脑的大细胞核进行染色。

Staining of the magnocellular nuclei of the rat hypothalamus by a monoclonal antibody directed against the alpha-subunit of the nicotinic cholinergic receptor.

作者信息

Mason W T

出版信息

Neurosci Lett. 1985 Aug 16;59(1):89-95. doi: 10.1016/0304-3940(85)90220-4.

DOI:10.1016/0304-3940(85)90220-4
PMID:3900818
Abstract

Previous work has shown the vasopressin-secreting cells of the supraoptic nucleus receive a cholinergic input from a region dorsolateral to the nucleus, and that acetylcholine (ACh) activation of these cells is blocked by nicotinic antagonists. This work reports that a monoclonal antibody, directed against the alpha-subunit of the nicotinic ACh receptor isolated from Electrophorus electricus, stains certain hypothalamic cells and processes, particularly in regions associated with vasopressin-containing neurones.

摘要

先前的研究表明，视上核分泌血管加压素的细胞接受来自该核背外侧区域的胆碱能输入，并且这些细胞的乙酰胆碱（ACh）激活被烟碱拮抗剂阻断。这项研究报告称，一种针对从电鳗分离出的烟碱型ACh受体α亚基的单克隆抗体，可使某些下丘脑细胞和突起着色，特别是在与含血管加压素神经元相关的区域。

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1
Staining of the magnocellular nuclei of the rat hypothalamus by a monoclonal antibody directed against the alpha-subunit of the nicotinic cholinergic receptor.用一种针对烟碱型胆碱能受体α亚基的单克隆抗体对大鼠下丘脑的大细胞核进行染色。
Neurosci Lett. 1985 Aug 16;59(1):89-95. doi: 10.1016/0304-3940(85)90220-4.
2
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[Demonstration of a different localization of perikarya immunoreactive to oxytocin and vasopressin in the cat hypothalamus].[猫下丘脑内对催产素和加压素免疫反应阳性的神经核周体的不同定位显示]
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Immunohistochemical analysis of magnocellular elements in rat hypothalamus: distribution and numbers of cells containing neurophysin, oxytocin, and vasopressin.大鼠下丘脑大细胞成分的免疫组织化学分析：含神经垂体素、催产素和加压素细胞的分布与数量
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J Neurosci. 1999 Aug 1;19(15):6475-87. doi: 10.1523/JNEUROSCI.19-15-06475.1999.
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Ultrastructural distribution of alpha-bungarotoxin binding sites in the suprachiasmatic nucleus of the rat hypothalamus.α-银环蛇毒素结合位点在大鼠下丘脑视交叉上核中的超微结构分布
Cell Tissue Res. 1987 Oct;250(1):13-20. doi: 10.1007/BF00214648.
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Surface and intracellular distribution of a putative neuronal nicotinic acetylcholine receptor.
一种假定的神经元烟碱型乙酰胆碱受体的表面和细胞内分布
J Cell Biol. 1986 Jul;103(1):205-14. doi: 10.1083/jcb.103.1.205.
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Immunohistochemical localization of a neuronal nicotinic acetylcholine receptor in mammalian brain.哺乳动物脑中一种神经元烟碱型乙酰胆碱受体的免疫组织化学定位
Proc Natl Acad Sci U S A. 1987 Dec;84(23):8697-701. doi: 10.1073/pnas.84.23.8697.
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Choline acetyltransferase immunocytochemical staining of the rat supraoptic nucleus and its surroundings. A light- and electron-microscopic study.
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Exp Brain Res. 1989;75(1):47-52. doi: 10.1007/BF00248529.
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